RT Journal Article
T1 Estimation of Admission D-dimer Cut-off Value to Predict Venous Thrombotic Events in Hospitalized COVID-19 Patients: Analysis of the SEMI-COVID-19 Registry.
A1 Garcia-Cervera, Carles
A1 Giner-Galvañ, Vicente
A1 Wikman-Jorgensen, Philip
A1 Laureiro, Jaime
A1 Rubio-Rivas, Manuel
A1 Gurjian-Arena, Anthony
A1 Arnalich-Fernandez, Francisco
A1 Beato-Perez, Jose Luis
A1 Vargas-Nuñez, Juan Antonio
A1 Gonzalez-Igual, Jesus Javier
A1 Diez-Manglano, Jesus
A1 Mendez-Bailon, Manuel
A1 Garcia-Blanco, Maria Jose
A1 Freire-Castro, Santiago J
A1 Aranda-Lobo, Judit
A1 Manzano, Luis
A1 Magallanes-Gamboa, Jeffrey Oskar
A1 Arribas-Perez, Luis
A1 Gonzalez-Moraleja, Julio
A1 Calderon-Hernaiz, Ruth
A1 Garcia-Alegria, Javier
A1 Gonzalez-Noya, Amara
A1 Gomez-Huelgas, Ricardo
A1 Lumbreras-Bermejo, Carlos
A1 Anton-Santos, Juan Miguel
K1 COVID-19
K1 D-dimer
K1 SARS-CoV-2
K1 Deep vein thrombosis
K1 Pulmonary embolism
K1 Venous thrombotic event
AB Venous thrombotic events (VTE) are frequent in COVID-19, and elevated plasma D-dimer (pDd) and dyspnea are common in both entities. To determine the admission pDd cut-off value associated with in-hospital VTE in patients with COVID-19. Multicenter, retrospective study analyzing the at-admission pDd cut-off value to predict VTE and anticoagulation intensity along hospitalization due to COVID-19. Among 9386 patients, 2.2% had VTE: 1.6% pulmonary embolism (PE), 0.4% deep vein thrombosis (DVT), and 0.2% both. Those with VTE had a higher prevalence of tachypnea (42.9% vs. 31.1%; p = 0.0005), basal O2 saturation 1.0 μg/ml treated with prophylactic dose (p 2.0 μg/ml treated with intermediate dose (p = 0.0001), and 31.3% for those with pDd >3.0 μg/ml and full anticoagulation (p = 0.0183). In hospitalized patients with COVID-19, a pDd value greater than 3.0 μg/ml can be considered to screen VTE and to consider full-dose anticoagulation.
PB Springer
YR 2021
FD 2021-07-21
LK http://hdl.handle.net/10668/18231
UL http://hdl.handle.net/10668/18231
LA en
NO García-Cervera C, Giner-Galvañ V, Wikman-Jorgensen P, Laureiro J, Rubio-Rivas M, Gurjian Arena A, et al. Estimation of Admission D-dimer Cut-off Value to Predict Venous Thrombotic Events in Hospitalized COVID-19 Patients: Analysis of the SEMI-COVID-19 Registry. J Gen Intern Med. 2021 Nov;36(11):3478-3486
DS RISalud
RD Apr 17, 2025