RT Journal Article
T1 Exploring the Ring-Closing Metathesis for the Construction of the Solomonamide Macrocyclic Core: Identification of Bioactive Precursors.
A1 Cheng-Sánchez, Iván
A1 Carrillo, Paloma
A1 Sánchez-Ruiz, Antonio
A1 Martínez-Poveda, Beatriz
A1 Quesada, Ana R
A1 Medina, Miguel A
A1 López-Romero, Juan M
A1 Sarabia, Francisco
AB New synthetic strategies directed toward the novel cyclopeptides solomonamides have been explored utilizing an olefin metathesis as the key reaction. In the various strategies investigated, we worked on minimally oxidized systems, and the olefin metathesis reaction demonstrated efficiency and validity for the construction of the macrocyclic core. The described synthetic strategies toward the solomonamides are well suited for the subsequent access to the natural products and represent flexible and diversity-oriented routes that allow for the generation of a variety of analogues via oxidative transformations. In addition, preliminary biological evaluations of the generated solomonamide precursors revealed antitumor activity against various tumor cell lines.
YR 2018
FD 2018-05-01
LK http://hdl.handle.net/10668/12374
UL http://hdl.handle.net/10668/12374
LA en
DS RISalud
RD Apr 10, 2025