RT Journal Article
T1 Modulation of the Endocannabinoids N-Arachidonoylethanolamine (AEA) and 2-Arachidonoylglycerol (2-AG) on Executive Functions in Humans.
A1 Fagundo, Ana B
A1 Torre, Rafael de la
A1 Jiménez-Murcia, Susana
A1 Agüera, Zaida
A1 Pastor, Antoni
A1 Casanueva, Felipe F
A1 Granero, Roser
A1 Baños, Rosa
A1 Botella, Cristina
A1 Pino-Gutiérrez, Amparo del
A1 Fernández-Real, José M
A1 Fernández-García, José C
A1 Frühbeck, Gema
A1 Gómez-Ambrosi, Javier
A1 Menchón, José M
A1 Moragrega, Inés
A1 Rodríguez, Roser
A1 Tárrega, Salomé
A1 Tinahones, Francisco J
A1 Fernández-Aranda, Fernando
K1 Endocannabinoides
K1 Receptores de cannabinoides
K1 Ácidos araquidónicos
K1 Sistema nervioso central
K1 Enfermedades neurodegenerativas
K1 Humanos
K1 Función ejecutiva
K1 Pruebas neuropsicológicas
K1 Abuso de marihuana
AB Animal studies point to an implication of the endocannabinoid system on executive functions. In humans, several studies have suggested an association between acute or chronic use of exogenous cannabinoids (Δ9-tetrahydrocannabinol) and executive impairments. However, to date, no published reports establish the relationship between endocannabinoids, as biomarkers of the cannabinoid neurotransmission system, and executive functioning in humans. The aim of the present study was to explore the association between circulating levels of plasma endocannabinoids N-arachidonoylethanolamine (AEA) and 2-Arachidonoylglycerol (2-AG) and executive functions (decision making, response inhibition and cognitive flexibility) in healthy subjects. One hundred and fifty seven subjects were included and assessed with the Wisconsin Card Sorting Test; Stroop Color and Word Test; and Iowa Gambling Task. All participants were female, aged between 18 and 60 years and spoke Spanish as their first language. Results showed a negative correlation between 2-AG and cognitive flexibility performance (r = -.37; p<.05). A positive correlation was found between AEA concentrations and both cognitive flexibility (r = .59; p<.05) and decision making performance (r = .23; P<.05). There was no significant correlation between either 2-AG (r = -.17) or AEA (r = -.08) concentrations and inhibition response. These results show, in humans, a relevant modulation of the endocannabinoid system on prefrontal-dependent cognitive functioning. The present study might have significant implications for the underlying executive alterations described in some psychiatric disorders currently associated with endocannabinoids deregulation (namely drug abuse/dependence, depression, obesity and eating disorders). Understanding the neurobiology of their dysexecutive profile might certainly contribute to the development of new treatments and pharmacological approaches.
PB Public Library of Science
YR 2013
FD 2013-06-19
LK http://hdl.handle.net/10668/1273
UL http://hdl.handle.net/10668/1273
LA en
NO Fagundo AB, de la Torre R, Jiménez-Murcia S, Agüera Z, Pastor A, Casanueva FF, et al. Modulation of the Endocannabinoids N-Arachidonoylethanolamine (AEA) and 2-Arachidonoylglycerol (2-AG) on Executive Functions in Humans. PLoS ONE. 2013; 8(6):e66387
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RD Apr 13, 2025