%0 Journal Article
%A Sotelo, Julio
%A Bächler, Pablo
%A Urbina, Jesús
%A Crelier, Gerard
%A Toro, Lida
%A Ferreiro, Myriam
%A Valverde, Israel
%A Andia, Marcelo
%A Tejos, Cristian
%A Irarrazaval, Pablo
%A Uribe, Sergio
%T Quantification of pulmonary regurgitation in patients with repaired Tetralogy of Fallot by 2D phase-contrast MRI: Differences between the standard method of velocity averaging and a pixel-wise analysis.
%D 2017
%@ 2048-0040
%U https://hdl.handle.net/10668/27320
%X To compare the values of pulmonary regurgitation in patients with repaired Tetralogy of Fallot quantified from two-dimensional phase-contrast data, by using a new pixel-wise analysis and the standard velocity-averaging method. Quantitative in silico and in vivo analysis. Hospital Sótero del Río. The magnetic resonance images were acquired using a Philips Achieva 1.5T scanner. Twenty-five patients with repaired Tetralogy of Fallot who underwent cardiovascular magnetic resonance imaging requested by their referring physicians were included in this study. Using a computational fluid dynamics simulation, we validated our pixel-wise method, quantifying the error of our method in comparison with the standard method. The patients underwent a standard two-dimensional phase-contrast magnetic resonance imaging acquisition for quantifying pulmonary artery flow. Pulmonary regurgitation fraction was estimated by using our pixel-wise and the standard method. The two-dimensional flow profiles were inspected looking for simultaneous antegrade and retrograde flows in the same cardiac phase. Statistical analysis was performed with t-test for related samples, Bland-Altman plots, and Pearson correlation coefficient. Estimation of pulmonary regurgitation fraction using the pixel-wise analysis revealed higher values compared with the standard method (39 ± 16% vs. 30 ± 22%, p-value  Quantification of pulmonary regurgitation fraction in patients with repaired Tetralogy of Fallot through a pixel-wise analysis yields higher values of pulmonary regurgitation compared with the standard velocity-averaging method.
%K Tetralogy of Fallot
%K magnetic resonance imaging
%K pulmonary valve insufficiency
%K two-dimensional flow
%~