TY - JOUR AU - Moreno-Fernández, R D AU - Pérez-Martín, M AU - Castilla-Ortega, E AU - Rosell Del Valle, C AU - García-Fernández, M I AU - Chun, J AU - Estivill-Torrús, G AU - Rodríguez de Fonseca, F AU - Santín, L J AU - Pedraza, C PY - 2017 DO - 10.1038/tp.2017.24 UR - http://hdl.handle.net/10668/2670 T2 - Translational Psychiatry AB - Anxious depression is a prevalent disease with devastating consequences and a poor prognosis. Nevertheless, the neurobiological mechanisms underlying this mood disorder remain poorly characterized. The LPA1 receptor is one of the six characterized G... LA - en PB - Nature Publishing Group KW - Animales KW - Antidepresivos KW - Ansiedad KW - Encéfalo KW - Depresión KW - Endofenotipos KW - Genotipo KW - Humanos KW - Lisofosfolípidos KW - Ratones KW - Ratones noqueados KW - Modelos animales KW - Trastornos del humor KW - Pánico KW - Pronóstico KW - Receptores del ácido lisofosfatídico KW - Medical Subject Headings::Psychiatry and Psychology::Behavior and Behavior Mechanisms::Neurobehavioral Manifestations::Anhedonia KW - Medical Subject Headings::Organisms::Eukaryota::Animals KW - Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Central Nervous System Agents::Psychotropic Drugs::Antidepressive Agents KW - Medical Subject Headings::Psychiatry and Psychology::Behavior and Behavior Mechanisms::Emotions::Anxiety KW - Medical Subject Headings::Anatomy::Nervous System::Central Nervous System::Brain KW - Medical Subject Headings::Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Behavioral Symptoms::Depression KW - Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Phenotype::Endophenotypes KW - Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genotype KW - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans KW - Medical Subject Headings::Chemicals and Drugs::Lipids::Membrane Lipids::Phospholipids::Glycerophosphates::Phosphatidic Acids::Lysophospholipids KW - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Mice KW - Medical Subject Headings::Organisms::Eukaryota::Animals::Animal Population Groups::Animals, Genetically Modified::Mice, Transgenic::Mice, Knockout KW - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Models, Animal KW - Medical Subject Headings::Psychiatry and Psychology::Mental Disorders::Mood Disorders KW - Medical Subject Headings::Psychiatry and Psychology::Behavior and Behavior Mechanisms::Emotions::Fear::Panic KW - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Prognosis KW - Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Membrane Proteins::Receptors, Cell Surface::Receptors, G-Protein-Coupled::Receptors, Lysophospholipid::Receptors, Lysophosphatidic Acid TI - maLPA1-null mice as an endophenotype of anxious depression TY - research article ER -