RT Journal Article
T1 White Button Mushroom Extracts Modulate Hepatic Fibrosis Progression, Inflammation, and Oxidative Stress In Vitro and in LDLR-/- Mice
A1 Gallego, Paloma
A1 Luque-Sierra, Amparo
A1 Falcon, Gonzalo
A1 Carbonero, Pilar
A1 Grande, Lourdes
A1 Bautista, Juan D.
A1 Martín, Franz
A1 Del Campo, José A.
K1 Atherosclerosis
K1 Hepatic fibrosis
K1 High-fat diet
K1 Inflammation
K1 Mushroom extract
K1 Oxidative stress
K1 Aterosclerosis
K1 Cirrosis hepática
K1 Alimentación rica en grasa
K1 Inflamación
K1 Agaricales
K1 Estrés oxidativo
K1 Agaricus campestris
AB Liver fibrosis can be caused by non-alcoholic steatohepatitis (NASH), among other conditions. We performed a study to analyze the effects of a nontoxic, water-soluble extract of the edible mushroom Agaricus bisporus (AB) as a potential inhibitor of fibrosis progression in vitro using human hepatic stellate cell (LX2) cultures and in vivo in LDLR-/- mice. Treatment of LX2 cells with the AB extract reduced the levels of fibrotic and oxidative-related markers and increased the levels of GATA4 expression. In LDLR-/- mice with high-fat diet (HFD)-induced liver fibrosis and inflammation, the progression of fibrosis, oxidative stress, inflammation, and apoptosis were prevented by AB extract treatment. Moreover, in the mouse model, AB extract could exert an antiatherogenic effect. These data suggest that AB mushroom extract seems to exert protective effects by alleviating inflammation and oxidative stress during the progression of liver fibrosis, possibly due to a decrease in Toll-like receptor 4 (TLR4) expression and a reduction in Nod-like receptor protein 3 (NLRP3) inflammasome activation. In addition, we observed a potential atheroprotective effect in our mouse model.
PB MDPI
YR 2021
FD 2021-08-01
LK http://hdl.handle.net/10668/4494
UL http://hdl.handle.net/10668/4494
LA en
NO Gallego P, Luque-Sierra A, Falcon G, Carbonero P, Grande L, Bautista JD, et al. White Button Mushroom Extracts Modulate Hepatic Fibrosis Progression, Inflammation, and Oxidative Stress In Vitro and in LDLR-/- Mice. Foods. 2021 Aug 1;10(8):1788
DS RISalud
RD Apr 6, 2025