RT Generic
T1 Pure Membranous Lupus Nephritis: Description of a Cohort of 150 Patients and Review of the Literature
A1 Silva-Fernandez, Lucia
A1 Oton, Teresa
A1 Askanase, Anca
A1 Carreira, Patricia
A1 Javier Lopez-Longo, Francisco
A1 Olive, Alejandro
A1 Rua-Figueroa, Inigo
A1 Narvaez, Javier
A1 Ruiz-Lucea, Esther
A1 Andres, Mariano
A1 Calvo, Enrique
A1 Toyos, Francisco
A1 Jose Alegre-Sancho, Juan
A1 Tomero, Eva
A1 Montilla, Carlos
A1 Zea, Antonio
A1 Uriarte, Esther
A1 Calvo-Alen, Jaime
A1 Marras, Carlos
A1 Martinez-Taboada, Victor M.
A1 Angeles Belmonte-Lopez, Maria
A1 Rosas, Jose
A1 Raya, Enrique
A1 Bonilla, Gema
A1 Freire, Mercedes
A1 Maria Pego-Reigosa, Jose
A1 Millan, Isabel
A1 Hughes-Morley, Adwoa
A1 Andreu, Jose Luis
A1 Spanish Soc Rheumatology Syst, 
K1 Systemic lupus erythematosus
K1 Membranous glomerulonephritis
K1 Retrospective review
K1 Long-term
K1 Mycophenolate-mofetil
K1 Cardiovascular-disease
K1 Revised criteria
K1 Chinese patients
K1 Erythematosus
K1 Nephropathy
K1 Cyclophosphamide
K1 Azathioprine
K1 Tacrolimus
AB Objectives: The course and long-term outcome of pure membranous lupus nephritis (MLN) are little understood. The aims of this study are to evaluate the clinical features, course, outcome and prognostic indicators in pure MLN and to determine the impact of ethnicity and the type of health insurance on the course and prognosis of pure MLN.Methods: We conducted a retrospective review of medical records of 150 patients with pure MLN from Spain and the USA.Results: Mean age was 34.2 +/- 12.5 and 80% were women. Sixty-eight percent of patients had nephrotic syndrome at diagnosis. The average serum creatinine was 0.98 +/- 0.78 mg/dl. Six percent of patients died and 5.3% developed end-stage renal disease (ESRD). ESRD was predicted by male sex, hypertension, dyslipidemia, high basal 24 h-proteinuria, high basal serum creatinine and a low basal creatinine clearance. Age, cardiac insufficiency, peripheral artheriopathy, hemodialysis and not having received mycophenolate mofetil or antimalarials for MLN predicted death.Conclusions: Pure MLN frequently presents with nephrotic syndrome, high proteinuria and normal serum creatinine. Its prognosis is favourable in maintaining renal function although proteinuria usually persists over time. Baseline cardiovascular disease and not having a health insurance are related with poor prognosis. (C) 2017 Elsevier Espana, S.L.U. and Sociedad Espanola de Reumatologia y Colegio Mexicano de Reumatologia. All rights reserved.
PB Elsevier doyma sl
SN 1699-258X
YR 2019
FD 2019-01-01
LK http://hdl.handle.net/10668/18876
UL http://hdl.handle.net/10668/18876
LA en
DS RISalud
RD Mar 14, 2025