RT Journal Article T1 Effect of a Lifestyle Intervention Program With Energy-Restricted Mediterranean Diet and Exercise on Weight Loss and Cardiovascular Risk Factors: One-Year Results of the PREDIMED-Plus Trial. A1 Salas-Salvado, Jordi A1 Diaz-Lopez, Andres A1 Ruiz-Canela, Miguel A1 Basora, Josep A1 Fito, Montse A1 Corella, Dolores A1 Serra-Majem, Luis A1 Wärnberg, Julia A1 Romaguera, Dora A1 Estruch, Ramon A1 Vidal, Josep A1 Martinez, J Alfredo A1 Aros, Fernando A1 Vazquez, Clotilde A1 Ros, Emilio A1 Vioque, Jesus A1 Lopez-Miranda, Jose A1 Bueno-Cavanillas, Aurora A1 Tur, Josep A A1 Tinahones, Francisco J A1 Martin, Vicente A1 Lapetra, Jose A1 Pinto, Xavier A1 Daimiel, Lidia A1 Delgado-Rodriguez, Miguel A1 Matia, Pilar A1 Gomez-Gracia, Enrique A1 Diez-Espino, Javier A1 Babio, Nancy A1 Castañer, Olga A1 Sorli, Jose V A1 Fiol, Miquel A1 Zulet, Maria Angeles A1 Bullo, Monica A1 Goday, Albert A1 Martinez-Gonzalez, Miguel A K1 Behavior therapy K1 Blood glucose K1 Caloric restriction K1 Cardiovascular diseases AB The long-term impact of intentional weight loss on cardiovascular events remains unknown. We describe 12-month changes in body weight and cardiovascular risk factors in PREvención con DIeta MEDiterránea (PREDIMED)-Plus, a trial designed to evaluate the long-term effectiveness of an intensive weight loss lifestyle intervention on primary cardiovascular prevention. Overweight/obese adults with metabolic syndrome aged 55-75 years (n = 626) were randomized to an intensive weight loss lifestyle intervention based on an energy-restricted Mediterranean diet, physical activity promotion, and behavioral support (IG) or a control group (CG). The primary and secondary outcomes were changes in weight and cardiovascular risk markers, respectively. Diet and physical activity changes were in the expected direction, with significant improvements in IG versus CG. After 12 months, IG participants lost an average of 3.2 kg vs. 0.7 kg in the CG (P PREDIMED-Plus intensive lifestyle intervention for 12 months was effective in decreasing adiposity and improving cardiovascular risk factors in overweight/obese older adults with metabolic syndrome, as well as in individuals with or at risk for diabetes. PB American Diabetes Association YR 2018 FD 2018-09-29 LK http://hdl.handle.net/10668/13151 UL http://hdl.handle.net/10668/13151 LA en NO Salas-Salvadó J, Díaz-López A, Ruiz-Canela M, Basora J, Fitó M, Corella D, et al. Effect of a Lifestyle Intervention Program With Energy-Restricted Mediterranean Diet and Exercise on Weight Loss and Cardiovascular Risk Factors: One-Year Results of the PREDIMED-Plus Trial. Diabetes Care. 2019 May;42(5):777-78 DS RISalud RD Apr 5, 2025