RT Journal Article
T1 Mild Social Stress in Mice Produces Opioid-Mediated Analgesia in Visceral but Not Somatic Pain States.
A1 Pitcher, Mark H
A1 Gonzalez-Cano, Rafael
A1 Vincent, Kathleen
A1 Lehmann, Michael
A1 Cobos, Enrique J
A1 Coderre, Terence J
A1 Baeyens, José M
A1 Cervero, Fernando
K1 Visceral pain
K1 mice
K1 somatic pain
K1 stress
K1 stress-induced analgesia
AB Visceral pain has a greater emotional component than somatic pain. To determine if the stress-induced analgesic response is differentially expressed in visceral versus somatic pain states, we studied the effects of a mild social stressor in either acute visceral or somatic pain states in mice. We show that the presence of an unfamiliar conspecific mouse (stranger) in an adjacent cubicle of a standard transparent observation box produced elevated plasma corticosterone levels compared with mice tested alone, suggesting that the mere presence of a stranger is stressful. We then observed noxious visceral or somatic stimulation-induced nociceptive behavior in mice tested alone or in mildly stressful conditions (ie, beside an unfamiliar stranger). Compared with mice tested alone, the presence of a stranger produced a dramatic opioid-dependent reduction in pain behavior associated with visceral but not somatic pain. This social stress-induced reduction of visceral pain behavior relied on visual but not auditory/olfactory cues. These findings suggest that visceral pain states may provoke heightened responsiveness to mild stressors, an effect that could interfere with testing outcomes during simultaneous behavioral testing of multiple rodents. In mice, mild social stress due to the presence of an unfamiliar conspecific mouse reduces pain behavior associated with noxious visceral but not somatic stimulation, suggesting that stress responsiveness may be enhanced in visceral pain versus somatic pain states.
YR 2017
FD 2017-02-20
LK http://hdl.handle.net/10668/10886
UL http://hdl.handle.net/10668/10886
LA en
DS RISalud
RD Apr 5, 2025