RT Journal Article
T1 Targeted Gene Delivery Therapies for Cervical Cancer
A1 Áyen, Ángela
A1 Jiménez Martínez, Yaiza
A1 Boulaiz, Houria
K1 Cervical cancer
K1 Targeted gene therapy
K1 Delivery systems
K1 Immunopotentiation
K1 Cervical cancer stem cells
K1 Neoplasias del cuello uterino
K1 Terapia genética
K1 Técnicas de transferencia de gen
K1 Sistema inmunológico
K1 Células madre neoplásicas
AB Despite being largely preventable through early vaccination and screening strategies, cervical cancer is the most common type of gynecological malignancy worldwide and constitutes one of the leading causes of cancer deaths in women. Patients with advanced or recurrent disease have a very poor prognosis; hence, novel therapeutic modalities to improve clinical outcomes in cervical malignancy are needed. In this regard, targeted gene delivery therapy is presented as a promising approach, which leads to the development of multiple strategies focused on different aspects. These range from altered gene restoration, immune system potentiation, and oncolytic virotherapy to the use of nanotechnology and the design of improved and enhanced gene delivery systems, among others. In the present manuscript, we review the current progress made in targeted gene delivery therapy for cervical cancer, the advantages and drawbacks and their clinical application. At present, multiple targeted gene delivery systems have been reported with encouraging preclinical results. However, the translation to humans has not yet shown a significant clinical benefit due principally to the lack of efficient vectors. Real efforts are being made to develop new gene delivery systems, to improve tumor targeting and to minimize toxicity in normal tissues.
PB MDPI
YR 2020
FD 2020-05-21
LK http://hdl.handle.net/10668/3729
UL http://hdl.handle.net/10668/3729
LA en
NO Áyen Á, Jiménez Martínez Y, Boulaiz H. Targeted Gene Delivery Therapies for Cervical Cancer. Cancers. 2020 May 21;12(5):1301
DS RISalud
RD Apr 19, 2025