RT Journal Article
T1 Prognostic role of genetic biomarkers in clinical progression of prostate cancer.
A1 Alvarez-Cubero, Maria Jesus
A1 Martinez-Gonzalez, Luis Javier
A1 Saiz, Maria
A1 Carmona-Saez, Pedro
A1 Alvarez, Juan Carlos
A1 Pascual-Geler, Manrique
A1 Lorente, Jose Antonio
A1 Cozar, Jose Manuel
K1 Biopsia
K1 Estudios de seguimiento
K1 Frecuencia de los genes
K1 Humanos
K1 Masculino
K1 Clasificación del tumor
K1 Nucleótidos
K1 Polimorfismo de nucleótido simple
K1 Antígeno prostático específico
K1 Neoplasias de la próstata
K1 Análisis de regresión
AB The aim of this study was to analyze the use of 12 single-nucleotide polymorphisms in genes ELAC2, RNASEL and MSR1 as biomarkers for prostate cancer (PCa) detection and progression, as well as perform a genetic classification of high-risk patients. A cohort of 451 men (235 patients and 216 controls) was studied. We calculated means of regression analysis using clinical values (stage, prostate-specific antigen, Gleason score and progression) in patients and controls at the basal stage and after a follow-up of 72 months. Significantly different allele frequencies between patients and controls were observed for rs1904577 and rs918 (MSR1 gene) and for rs17552022 and rs5030739 (ELAC2). We found evidence of increased risk for PCa in rs486907 and rs2127565 in variants AA and CC, respectively. In addition, rs627928 (TT-GT), rs486907 (AG) and rs3747531 (CG-CC) were associated with low tumor aggressiveness. Some had a weak linkage, such as rs1904577 and rs2127565, rs4792311 and rs17552022, and rs1904577 and rs918. Our study provides the proof-of-principle that some of the genetic variants (such as rs486907, rs627928 and rs2127565) in genes RNASEL, MSR1 and ELAC2 can be used as predictors of aggressiveness and progression of PCa. In the future, clinical use of these biomarkers, in combination with current ones, could potentially reduce the rate of unnecessary biopsies and specific treatments.
PB Nature Publishing Group
SN 1226-3613
YR 2015
FD 2015-08-07
LK http://hdl.handle.net/10668/2058
UL http://hdl.handle.net/10668/2058
LA en
NO Alvarez-Cubero MJ, Martinez-Gonzalez LJ, Saiz M, Carmona-Saez P, Alvarez JC, Pascual-Geler M, et al. Prognostic role of genetic biomarkers in clinical progression of prostate cancer. Exp. Mol. Med. 2015; 47:e176
NO Journal Article;
DS RISalud
RD Apr 11, 2025