RT Journal Article
T1 Subclinical cardiovascular risk signs in adults with juvenile idiopathic arthritis in sustained remission.
A1 Aranda-Valera, Inmaculada Concepcion
A1 Arias de la Rosa, Ivan
A1 Roldan-Molina, Rosa
A1 Abalos-Aguilera, María Del Carmen
A1 Torres-Granados, Carmen
A1 Patiño-Trives, Alejandra
A1 Luque-Tevar, Maria
A1 Ibañez-Costa, Alejandro
A1 Guzman-Ruiz, Rocio
A1 Malagon, Maria Del Mar
A1 Escudero-Contreras, Alejandro
A1 Lopez-Pedrera, Chary
A1 Collantes-Estevez, Eduardo
A1 Barbarroja, Nuria
K1 Cardiovascular risk
K1 Clinical remission
K1 Juvenile idiopathic arthritis
AB Juvenile Idiopathic Arthritis (JIA) is one of the most common chronic diseases of childhood that often persists into adulthood and can result in significant long-term morbidity. As a long lasting chronic inflammatory disease, concern has been raised regarding the risk of premature development of cardiovascular disease (CVD) in JIA. This study aims to determine whether adults with JIA in clinical remission display clinical and subclinical signs of CVD risk: inflammatory mediators, adipokines, endothelial dysfunction and oxidative stress markers. This is a cross-sectional study including 25 patients diagnosed with JIA according to the International League of Associations for Rheumatology criteria (ILAR 2001) and 25 age- and sex-matched controls. Remission was determined by JADAS10  Mean duration of the disease was 13.47 ± 5.47 years. Mean age was 25.11 ± 7.21. Time in remission was 3.52 ± 3.33 years. Patients were in remission with no treatment (40%) and with treatments (60%). CVD risk factors and CIMT were similar in JIA patients and controls. However, cholesterol levels were significantly elevated in JIA patients. Levels of adipocytokines, oxidative stress and endothelial activation markers were elevated in serum and PBMCs from JIA patients. Serum of those JIA patients induced the activation of adipocytes, endothelial cells and healthy PBMCs. JIA adult patients in remission have subclinical signs of inflammation and CVD risk, showed by an increase in the levels of inflammatory cytokines, endothelial activation and oxidative stress markers and adipokines, molecules closely involved in the alteration of the vascular system.
PB BioMed Central Ltd.
YR 2020
FD 2020-07-03
LK http://hdl.handle.net/10668/15935
UL http://hdl.handle.net/10668/15935
LA en
NO Aranda-Valera IC, Arias de la Rosa I, Roldán-Molina R, Ábalos-Aguilera MDC, Torres-Granados C, Patiño-Trives A, et al. Subclinical cardiovascular risk signs in adults with juvenile idiopathic arthritis in sustained remission. Pediatr Rheumatol Online J. 2020 Jul 14;18(1):59.
NO This work was supported by a grant from the Spanish Society of Pediatric Rheumatology (Moving4 grant, call 2018) and Rheumatic Diseases Network (RIER), Instituto de Salud Carlos III (RD16/0012/0015). C.L‐P was supported by a contract from the Spanish Junta de Andalucía (“Nicolas Monardes” program).
DS RISalud
RD Apr 17, 2025