RT Journal Article
T1 Comparison of seven prognostic tools to identify low-risk pulmonary embolism in patients aged <50 years.
A1 Jara-Palomares, Luis
A1 Alfonso, Maria
A1 Maestre, Ana
A1 Jimenez, David
A1 Garcia-Bragado, Fernando
A1 Font, Carme
A1 Reyes, Raquel Lopez
A1 Blasco, Luis Hernandez
A1 Vidal, Gemma
A1 Otero, Remedios
A1 Monreal, Manuel
K1 Thromboembolism
K1 Embolism
K1 Disease-free survival
AB In young patients with acute pulmonary embolism (PE), the predictive value of currently available prognostic tools has not been evaluated. Our objective was to compare prognostic value of 7 available tools (GPS, PESI, sPESI, Prognostic Algorithm , PREP, shock index and RIETE) in patients aged <50 years. We used the RIETE database, including PE patients from 2001 to 2017. The major outcome was 30-day all-cause mortality . Of 34,651 patients with acute PE, 5,822 (17%) were aged <50 years. Of these, 83 (1.4%) died during the first 30 days. Number of patients deemed low risk with tools was: PREP (95.9%), GPS (89.6%), PESI (87.2%), Shock index (70.9%), sPESI (59.4%), Prognostic algorithm (58%) and RIETE score (48.6%). The tools with a highest sensitivity were: Prognostic Algorithm (91.6%; 95% CI: 85.6–97.5), RIETE score (90.4%; 95%CI: 84.0–96.7) and sPESI (88%; 95% CI: 81–95). The RIETE, Prognostic Algorithm and sPESI scores obtained the highest overall sensitivity estimates for also predicting 7- and 90-day all-cause mortality , 30-day PE-related mortality , 30-day major bleeding and 30-day VTE recurrences . The proportion of low- risk patients who died within the first 30 days was lowest using the Prognostic Algorithm (0.2%), RIETE (0.3%) or sPESI (0.3%) scores. In PE patients less 50 years, 30-day mortality was low. Although sPESI, RIETE and Prognostic Algorithm scores were the most sensitive tools to identify patients at low risk to die, other tools should be evaluated in this population to obtain more efficient results.
YR 2019
FD 2019-12-27
LK http://hdl.handle.net/10668/14896
UL http://hdl.handle.net/10668/14896
LA en
NO Jara-Palomares L, Alfonso M, Maestre A, Jimenez D, Garcia-Bragado F, Font C, et al. Comparison of seven prognostic tools to identify low-risk pulmonary embolism in patients aged <50 years. Sci Rep. 2019 Dec 27;9(1):20064.
DS RISalud
RD Jul 4, 2025