RT Journal Article
T1 Cognitive status among patients with chronic obstructive pulmonary disease
A1 Roncero, Carlos
A1 Isabel Campuzano, Ana
A1 Antonio Quintano, Jose
A1 Molina, Jesus
A1 Perez, Joselin
A1 Miravitlles, Marc
K1 chronic obstructive pulmonary disease
K1 cognitive function
K1 mini-mental state examination
K1 depression
K1 quality of life
K1 comorbidity
K1 Beck depression inventory
K1 Spanish version
K1 Psychometric properties
K1 Physical-activity
K1 Health-status
K1 Copd
K1 Exacerbations
K1 Dysfunction
K1 Impairment
K1 Prevalence
AB Purpose: We investigated the association between cognitive impairment and chronic obstructive pulmonary disease (COPD), taking into account demographic and clinical variables evaluated during routine practice.Patients and methods: We performed a post hoc analysis of a cross-sectional study that included subjects with stable COPD. Sociodemographic and clinical information was recorded using the Body mass index, airflow Obstruction, Dyspnea and Exacerbations index and the Charlson comorbidity index. Cognitive performance was studied by the mini-mental state examination, with a score less than 27 indicating clinical impairment. Depressive symptoms, physical activity, and quality of life (EuroQoL-5 dimensions and COPD Assessment Test) were also evaluated.Results: The analysis included 940 subjects. The prevalence of cognitive impairment was 39.4%. Multivariate logistic regression models revealed that cognitive impairment was associated with educational level (odds ratio [OR] = 0.096, 95% confidence interval [CI] = 0.011-0.447) and poorer quality of life measured by the EuroQoL-5 dimensions social tariff (OR = 0.967, 95% CI = 0.950-0.983). When questionnaires were not included in the analysis, cognitive impairment was associated with educational level (OR = 0.063, 95% CI = 0.010-0.934), number of exacerbations (OR = 11.070, 95% CI = 1.450-84.534), Body mass index, airflow Obstruction, Dyspnea and Exacerbations index score (OR = 1.261, 95% CI = 1.049-1.515), and the Charlson comorbidity index (OR = 1.412, 95% CI = 1.118-1.783).Conclusion: Cognitive impairment is common in COPD and is associated with low educational level, higher disease severity, and increased comorbidity. This could have therapeutic implications for this population.
PB Dove medical press ltd
SN 1178-2005
YR 2016
FD 2016-01-01
LK https://hdl.handle.net/10668/25312
UL https://hdl.handle.net/10668/25312
LA en
DS RISalud
RD Apr 12, 2025