RT Journal Article
T1 Inflammatory potential of diet and risk of lymphoma in the European Prospective Investigation into Cancer and Nutrition.
A1 Solans, Marta
A1 Benavente, Yolanda
A1 Saez, Marc
A1 Agudo, Antonio
A1 Jakszyn, Paula
A1 Naudin, Sabine
A1 Hosnijeh, Fatemeh Saberi
A1 Gunter, Marc
A1 Huybrechts, Inge
A1 Ferrari, Pietro
A1 Besson, Caroline
A1 Mahamat-Saleh, Yahya
A1 Boutron-Ruault, Marie-Christine
A1 Kühn, Tilman
A1 Kaaks, Rudolf
A1 Boeing, Heiner
A1 Lasheras, Cristina
A1 Sanchez-Perez, Maria-Jose
A1 Amiano, Pilar
A1 Chirlaque, Maria Dolores
A1 Ardanaz, Eva
A1 Schmidt, Julie A
A1 Vineis, Paolo
A1 Riboli, Elio
A1 Trichopoulou, Antonia
A1 Karakatsani, Anna
A1 Valanou, Elisavet
A1 Masala, Giovanna
A1 Agnoli, Claudia
A1 Tumino, Rosario
A1 Sacerdote, Carlotta
A1 Mattiello, Amalia
A1 Skeie, Guri
A1 Weiderpass, Elisabete
A1 Jerkeman, Mats
A1 Dias, Joana Alves
A1 Späth, Florentin
A1 Nilsson, Lena Maria
A1 Dahm, Christina C
A1 Overvad, Kim
A1 Petersen, Kristina Elin Nielsen
A1 Tjønneland, Anne
A1 de Sanjose, Silvia
A1 Vermeulen, Roel
A1 Nieters, Alexandra
A1 Casabonne, Delphine
K1 Chronic inflammation
K1 Inflammatory score of the diet
K1 Lymphoma
K1 Nutrition
K1 Prospective studies
AB Chronic inflammation plays a critical role in lymphomagenesis and several dietary factors seem to be involved its regulation. The aim of the current study was to assess the association between the inflammatory potential of the diet and the risk of lymphoma and its subtypes in the European Investigation into Cancer and Nutrition (EPIC) study. The analysis included 476,160 subjects with an average follow-up of 13.9 years, during which 3,136 lymphomas (135 Hodgkin lymphoma (HL), 2606 non-Hodgkin lymphoma (NHL) and 395 NOS) were identified. The dietary inflammatory potential was assessed by means of an inflammatory score of the diet (ISD), calculated using 28 dietary components and their corresponding inflammatory weights. The association between the ISD and lymphoma risk was estimated by hazard ratios (HR) and 95% confidence intervals (CI) calculated by multivariable Cox regression models adjusted for potential confounders. The ISD was not associated with overall lymphoma risk. Among lymphoma subtypes, a positive association between the ISD and mature B-cell NHL (HR for a 1-SD increase: 1.07 (95% CI 1.01; 1.14), p trend = 0.03) was observed. No statistically significant association was found among other subtypes. However, albeit with smaller number of cases, a suggestive association was observed for HL (HR for a 1-SD increase = 1.22 (95% CI 0.94; 1.57), p trend 0.13). Our findings suggested that a high ISD score, reflecting a pro-inflammatory diet, was modestly positively associated with the risk of B-cell lymphoma subtypes. Further large prospective studies on low-grade inflammation induced by diet are warranted to confirm these findings.
PB Springer Medizin
YR 2019
FD 2019-03-11
LK http://hdl.handle.net/10668/13751
UL http://hdl.handle.net/10668/13751
LA en
NO Solans M, Benavente Y, Saez M, Agudo A, Jakszyn P, Naudin S, et al.  Inflammatory potential of diet and risk of lymphoma in the European Prospective Investigation into Cancer and Nutrition. Eur J Nutr. 2020 Mar;59(2):813-823.
NO uropean Commission (DG-SANCO), International Agency for Research on Cancer, Danish Cancer Society (Denmark), Ligue Contre le Cancer, Institut Gustave Roussy, Mutuelle Generale de l’Education Nationale, Institut National de la Sante et de la Recherche Medicale (INSERM) (France), German Cancer Aid, German Cancer Research Center (DKFZ), Federal Ministry of Education and Research (BMBF), Deutsche Krebshilfe, Deutsches Krebsforschungszentrum and Federal Ministry of Education and Research (Germany), the Hellenic Health Foundation (Greece), Associazione Italiana per la Ricerca sul Cancro-AIRC-Italy and National Research Council (Italy), Dutch Ministry of Public Health, Welfare and Sports (VWS), Netherlands Cancer Registry (NKR), LK Research Funds, Dutch Prevention Funds, Dutch ZON (Zorg Onderzoek Nederland), World Cancer Research Fund (WCRF), Statistics Netherlands (The Netherlands); German Federal Ministry of Education and Research (BMBF 01EO1303); Grant sponsor: Spanish Ministry of Economy and Competitiveness-Carlos III Institute of Health cofunded by FEDER funds/European Regional Development Fund (ERDF)—a way to build Europe, Grant numbers: [PI13/00061 (to Granada), PI13/01162 (to EPIC-Murcia, Regional Governments of Andalucıa, Asturias, Basque Country, Murcia and Navarra), PI17/01280 and PI14/01219 (to Barcelona), Centro de Investigación Biomédica en Red: Epidemiología y Salud Pública (CIBERESP, Spain)]; Grant sponsor: Agència de Gestió d’Ajuts Universitaris i de Recerca (AGAUR), CERCA Programme / Generalitat de Catalunya for institutional support; Grant number (2017SGR1085); Grant sponsors: Swedish Cancer Society, Swedish Research Council and County Councils of Skåne and Vasterbotten (Sweden) and Cancer Research UK; Grant numbers: 14136 (to EPIC-Norfolk), C570/A16491 and C8221/A19170 (to EPIC-Oxford); Grant sponsor: Medical Research Council; Grant numbers: 1000143 (to EPIC-Norfolk), MR/M012190/1 (to EPIC-Oxford, UK).
DS RISalud
RD Apr 7, 2025