RT Journal Article
T1 Assessing cardiovascular risk in hepatitis C: An unmet need.
A1 Ampuero, Javier
A1 Romero-Gómez, Manuel
K1 Hepatitis C
K1 Atherosclerosis
K1 Coronary  artery  disease
K1 Cardiovascular risk
K1 Oxidative stress
K1 Inflammation
K1 Proteína C-reactiva
K1 Carcinoma hepatocelular
K1 Enfermedad de la arteria coronaria
K1 Hepatitis C
AB Chronic hepatitis C virus (HCV) is associated with significant morbidity and mortality, as a result of the progression towards cirrhosis and hepatocellular carcinoma. Additionally, HCV seems to be an independent risk factor for cardiovascular diseases (CVD) due to its association with insulin resistance, diabetes and steatosis. HCV infection represents an initial step in the chronic inflammatory cascade, showing a direct role in altering glucose metabolism. After achieving sustained virological response, the incidence of insulin resistance and diabetes dramatically decrease. HCV core protein plays an essential role in promoting insulin resistance and oxidative stress. On the other hand, atherosclerosis is a common disease in which the artery wall thickens due to accumulation of fatty deposits. The main step in the formation of atherosclerotic plaques is the oxidation of low density lipoprotein particles, together with the increased production of proinflammatory markers [tumor necrosis factor-α, interleukin (IL)-6, IL-18 or C-reactive protein]. The advent of new direct acting antiviral therapy has dramatically increased the sustained virological response rates of hepatitis C infection. In this scenario, the cardiovascular risk has emerged and represents a major concern after the eradication of the virus. Consequently, the number of studies evaluating this association is growing. Data derived from these studies have demonstrated the strong link between HCV infection and the atherogenic process, showing a higher risk of coronary heart disease, carotid atherosclerosis, peripheral artery disease and, ultimately, CVD-related mortality.
PB Baishideng Publishing Group Co. Limited
YR 2015
FD 2015-09-08
LK http://hdl.handle.net/10668/2126
UL http://hdl.handle.net/10668/2126
LA en
NO Ampuero J, Romero-Gómez M. Assessing cardiovascular risk in hepatitis C: An unmet need. World J Hepatol. 2015; 7(19):2214-9
NO Journal Article; Review;
DS RISalud
RD Apr 8, 2025