RT Journal Article
T1 Markers of endothelial damage in patients with chronic kidney disease on hemodialysis.
A1 Carmona, Andres
A1 Agüera, Maria L
A1 Luna-Ruiz, Carlos
A1 Buendia, Paula
A1 Calleros, Laura
A1 Garcia-Jerez, Andrea
A1 Rodriguez-Puyol, Manuel
A1 Arias, Manuel
A1 Arias-Guillen, Marta
A1 de Arriba, Gabriel
A1 Ballarin, Jose
A1 Bernis, Carmen
A1 Fernandez, Elvira
A1 Garcia-Rebollo, Sagrario
A1 Mancha, Javier
A1 Del Peso, Gloria
A1 Perez, Estefania
A1 Poch, Esteban
A1 Portoles, Jose M
A1 Rodriguez-Puyol, Diego
A1 Sanchez-Villanueva, Rafael
A1 Sarro, Felipe
A1 Torres, Armando
A1 Martin-Malo, Alejandro
A1 Aljama, Pedro
A1 Ramirez, Rafael
A1 Carracedo, Julia
K1 Cardiovascular disease
K1 Chronic kidney disease
K1 Diabetes mellitus
K1 Inflammation, hemodialysis
K1 Microvesicles
AB Patients with Stage 5 chronic kidney disease who are on hemodialysis (HD) remain in a chronic inflammatory state, characterized by the accumulation of uremic toxins that induce endothelial damage and cardiovascular disease (CVD). Our aim was to examine microvesicles (MVs), monocyte subpopulations, and angiopoietins (Ang) to identify prognostic markers in HD patients with or without diabetes mellitus (DM). A total of 160 prevalent HD patients from 10 centers across Spain were obtained from the Biobank of the Nephrology Renal Network (Madrid, Spain): 80 patients with DM and 80 patients without DM who were matched for clinical and demographic criteria. MVs from plasma and several monocyte subpopulations (CD142+/CD16+, CD14+/CD162+) were analyzed by flow cytometry, and the plasma concentrations of Ang1 and Ang2 were quantified by ELISA. Data on CVD were gathered over the 5.5 yr after these samples were obtained. MV level, monocyte subpopulations (CD14+/CD162+ and CD142+/CD16+), and Ang2-to-Ang1 ratios increased in HD patients with DM compared with non-DM patients. Moreover, MV level above the median (264 MVs/µl) was associated independently with greater mortality. MVs, monocyte subpopulations, and Ang2-to-Ang1 ratio can be used as predictors for CVD. In addition, MV level has a potential predictive value in the prevention of CVD in HD patients. These parameters undergo more extensive changes in patients with DM.
PB American Physiological Society
YR 2017
FD 2017-01-09
LK http://hdl.handle.net/10668/10764
UL http://hdl.handle.net/10668/10764
LA en
NO Carmona A, Agüera ML, Luna-Ruiz C, Buendía P, Calleros L, García-Jerez A, et al. Markers of endothelial damage in patients with chronic kidney disease on hemodialysis. Am J Physiol Renal Physiol. 2017 Apr 1;312(4):F673-F681
DS RISalud
RD Apr 13, 2025