RT Journal Article
T1 Local Respiratory Allergy: From Rhinitis Phenotype to Disease Spectrum
A1 Testera-Montes, Almudena
A1 Salas, Maria
A1 Palomares, Francisca
A1 Ariza, Adriana
A1 Torres, María J.
A1 Rondón, Carmen
A1 Eguiluz-Gracia, Ibon
K1 Allergic rhinitis
K1 Dual allergic rhinitis
K1 Local allergic rhinitis
K1 Local allergic asthma
K1 Local respiratory allergy
K1 Mucosal immunology
K1 IgE synthesis
K1 Rinitis alérgica
K1 Enfermedad local
K1 Asma
K1 Alergia e inmunología
K1 Inmunidad mucosa
K1 Inmunoglobulina E
AB Local respiratory allergy (LRA) is defined by the negativity of atopy tests, a clinical history suggestive of airway allergy and a positive response to the nasal and/or bronchial allergen challenge. The clinical spectrum of LRA is comprised of three conditions: local allergic rhinitis (LAR) and local allergic asthma in non-atopic patients, and dual allergic rhinitis (coexistence of allergic rhinitis and LAR) in atopic individuals. LRA is an independent disease phenotype not progressing to atopy over time, but naturally evolving to the clinical worsening and the onset of comorbidities. Published data suggests that LRA is mediated through the mucosal synthesis of allergen-specific (s)IgE, which binds to FcϵRI on resident mast cells, and in >50% of cases traffics to the blood stream to sensitize circulating basophils. To date, 4 clinical trials have demonstrated the capacity of allergen immunotherapy (AIT) to decrease nasal, conjunctival and bronchial symptoms, to improve quality of life, to increase the threshold dose of allergen eliciting respiratory symptoms, and to induce serum sIgG4 in LRA individuals. Collectively, these data indicate that local allergy is a relevant disease mechanisms in both atopic and non-atopic patients with airway diseases.
PB Frontiers
YR 2021
FD 2021-06-02
LK http://hdl.handle.net/10668/4159
UL http://hdl.handle.net/10668/4159
LA en
NO Testera-Montes A, Salas M, Palomares F, Ariza A, Torres MJ, Rondón C, et al. Local Respiratory Allergy: From Rhinitis Phenotype to Disease Spectrum. Front Immunol. 2021 Jun 2;12:691964
DS RISalud
RD Apr 10, 2025