RT Journal Article
T1 Circulating Undercarboxylated Osteocalcin as Estimator of Cardiovascular and Type 2 Diabetes Risk in Metabolic Syndrome Patients
A1 Riquelme-Gallego, Blanca
A1 García-Molina, Laura
A1 Cano-Ibáñez, Naomi
A1 Sánchez-Delgado, Guillermo
A1 Andújar-Vera, Francisco
A1 García-Fontana, Cristina
A1 González-Salvatierra, Sheila
A1 García-Recio, Enrique
A1 Martínez-Ruiz, Virginia
A1 Bueno-Cavanillas, Aurora
A1 Muñoz-Torres, Manuel
A1 García-Fontana, Beatriz
K1 Osteocalcin
K1 Diabetes mellitus
K1 Cardiovascular diseases
K1 Metabolic syndrome
K1 Risk factors
K1 Biomarkers
K1 Osteocalcina
K1 Enfermedades cardiovasculares
K1 Síndrome metabólico
K1 Factores de riesgo
K1 Biomarcadores
AB Undercarboxylated osteocalcin (ucOC) could be a biomarker of glucose disturbances and cardiovascular risk. Our study aimed to determine the association between serum levels of ucOC and cardiovascular risk in metabolic syndrome (MetS) patients and to analyse its potential role as estimator of type 2 diabetes (T2D) risk in this population. This cross-sectional study included 235 patients with MetS, 53.2% women, aged 55-75 years. Circulating ucOC levels were measured by ELISA. Cardiovascular risk was determined as Z-score of the diagnostic criteria for MetS (CV-ZS). Linear regression model was performed to analyse the association between circulating ucOC and CV-ZS. A receiver operating curve (ROC) was performed to analyse the usefulness of ucOC as T2D risk estimator. Patients above the CV-ZS median showed significant lower ucOC levels. We found an inverse association between ucOC levels and CV-ZS in MetS patients without T2D. Patients with ucOC levels below the 25th percentile showed worse cardiometabolic profile and higher cardiovascular and T2D risk. The area under the curve performed better when ucOC levels were included along with the classic T2D risk factors. The measurement of circulating ucOC could be a useful tool to identify increased cardiovascular and T2D risk in MetS patients without T2D.
PB Springer Nature
YR 2020
FD 2020-02-04
LK http://hdl.handle.net/10668/3919
UL http://hdl.handle.net/10668/3919
LA en
NO Riquelme-Gallego B, García-Molina L, Cano-Ibáñez N, Sánchez-Delgado G, Andújar-Vera F, García-Fontana C, et al. Circulating Undercarboxylated Osteocalcin as Estimator of Cardiovascular and Type 2 Diabetes Risk in Metabolic Syndrome Patients. Sci Rep. 2020 Feb 4;10(1):1840
DS RISalud
RD Apr 11, 2025