RT Journal Article
T1 Caenorhabditis elegans as a model for understanding ROS function in physiology and disease.
A1 Miranda-Vizuete, Antonio
A1 Veal, Elizabeth A
K1 Aging
K1 Caenorhabditis elegans
K1 Cuticle
K1 Innate immunity
K1 Pathogen infection
K1 ROS detection
K1 Reactive oxygen species
K1 Redox homeostasis
K1 Wound healing
AB ROS (reactive oxygen species) are potentially damaging by-products of aerobic metabolism which, unchecked, can have detrimental effects on cell function. However, it is now widely accepted that, at physiological levels, certain ROS play important roles in cell signaling, acting as second messengers to regulate cell choices that contribute to the development, adaptation and survival of plants and animals. Despite important recent advances in the biochemical tools available to study redox-signaling, the molecular mechanisms underlying most of these responses remain poorly understood, particularly in multicellular organisms. As we will review here, C. elegans has emerged as a powerful animal model to elucidate these and other aspects of redox biology.
PB Elsevier BV
YR 2016
FD 2016-12-27
LK http://hdl.handle.net/10668/10863
UL http://hdl.handle.net/10668/10863
LA en
NO Miranda-Vizuete A, Veal EA. Caenorhabditis elegans as a model for understanding ROS function in physiology and disease. Redox Biol. 2017 Apr;11:708-714.
DS RISalud
RD Apr 10, 2025