RT Journal Article
T1 Pre-diagnostic concordance with the WCRF/AICR guidelines and survival in European colorectal cancer patients: a cohort study.
A1 Romaguera, Dora
A1 Ward, Heather
A1 Wark, Petra A
A1 Vergnaud, Anne-Claire
A1 Peeters, Petra H
A1 van Gils, Carla H
A1 Ferrari, Pietro
A1 Fedirko, Veronika
A1 Jenab, Mazda
A1 Boutron-Ruault, Marie-Christine
A1 Dossus, Laure
A1 Dartois, Laureen
A1 Hansen, Camilla Plambeck
A1 Dahm, Christina Catherine
A1 Buckland, Genevieve
A1 Sanchez-Perez, Maria-Jose
A1 Dorronsoro, Miren
A1 Navarro, Carmen
A1 Barricarte, Aurelio
A1 Key, Timothy J
A1 Trichopoulou, Antonia
A1 Tsironis, Christos
A1 Lagiou, Pagona
A1 Masala, Giovanna
A1 Pala, Valeria
A1 Tumino, Rosario
A1 Vineis, Paolo
A1 Panico, Salvatore
A1 Bueno-de-Mesquita, H Bas
A1 Siersema, Peter D
A1 Ohlsson, Bodil
A1 Jirström, Karin
A1 Wennberg, Maria
A1 Nilsson, Lena M
A1 Weiderpass, Elisabete
A1 Kühn, Tilman
A1 Katzke, Verena
A1 Khaw, Kay-Tee
A1 Wareham, Nick J
A1 Tjønneland, Anne
A1 Boeing, Heiner
A1 Quirós, José R
A1 Gunter, Marc J
A1 Riboli, Elio
A1 Norat, Teresa
K1 Colorectal cancer
K1 Diet
K1 Healthy lifestyle
K1 Physical activity
K1 Survival
K1 Weight
K1 Estudios de Cohortes
K1 Sobrevivientes
K1 Neoplasias Colorrectales
K1 Dieta
K1 Estilo de Vida
K1 Actividad Motora
AB BACKGROUNDCancer survivors are advised to follow lifestyle recommendations on diet, physical activity, and body fatness proposed by the World Cancer Research Fund/American Institute of Cancer Research (WCRF/AICR) for cancer prevention. Previous studies have demonstrated that higher concordance with these recommendations measured using an index score (the WCRF/AICR score) was associated with lower cancer incidence and mortality. The aim of this study was to evaluate the association between pre-diagnostic concordance with WCRF/AICR recommendations and mortality in colorectal cancer (CRC) patients.METHODSThe association between the WCRF/AICR score (score range 0-6 in men and 0-7 in women; higher scores indicate greater concordance) assessed on average 6.4 years before diagnosis and CRC-specific (n = 872) and overall mortality (n = 1,113) was prospectively examined among 3,292 participants diagnosed with CRC in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort (mean follow-up time after diagnosis 4.2 years). Multivariable Cox proportional hazard models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for mortality.RESULTSThe HRs (95% CIs) for CRC-specific mortality among participants in the second (score range in men/women: 2.25-2.75/3.25-3.75), third (3-3.75/4-4.75), and fourth (4-6/5-7) categories of the score were 0.87 (0.72-1.06), 0.74 (0.61-0.90), and 0.70 (0.56-0.89), respectively (P for trend <0.0001), compared to participants with the lowest concordance with the recommendations (category 1 of the score: 0-2/0-3). Similar HRs for overall mortality were observed (P for trend 0.004). Meeting the recommendations on body fatness and plant food consumption were associated with improved survival among CRC cases in mutually adjusted models.CONCLUSIONSGreater concordance with the WCRF/AICR recommendations on diet, physical activity, and body fatness prior to CRC diagnosis is associated with improved survival among CRC patients.
PB BioMed Central
YR 2015
FD 2015-05-07
LK http://hdl.handle.net/10668/1986
UL http://hdl.handle.net/10668/1986
LA en
NO Romaguera D, Ward H, Wark PA, Vergnaud AC, Peeters PH, van Gils CH, et al. Pre-diagnostic concordance with the WCRF/AICR guidelines and survival in European colorectal cancer patients: a cohort study. BMC Med 2015; 13(1):107
NO Journal Article;
DS RISalud
RD Apr 11, 2025