RT Journal Article
T1 Development of a Score to Predict the Paroxysmal Atrial Fibrillation in Stroke Patients: The Screening for Atrial Fibrillation Scale.
A1 Amaya Pascasio, Laura
A1 Quesada Lopez, Miguel
A1 Garcia-Torrecillas, Juan Manuel
A1 Arjona-Padillo, Antonio
A1 Martinez Sanchez, Patricia
K1 ESUS
K1 atrial fibrillation
K1 embolic stroke
K1 embolic stroke of undetermined source
K1 ischemic stroke
AB An individual selection of ischemic stroke patients at higher risk of atrial fibrillation (AF) might increase the diagnostic yield of prolonged cardiac monitoring and render it cost-effective. The clinical, laboratory, and brain/cardiac imaging characteristics of consecutive ischemic stroke patients without documented AF were recorded. All patients underwent at least 72 h of cardiac monitoring unless AF was diagnosed before, transthoracic echocardiogram, blood biomarkers, and intracranial vessels imaging. A predictive grading was developed by logistic regression analysis, the screening for atrial fibrillation scale (SAFE). A total of 460 stroke patients were analyzed to develop the SAFE scale, a 7-items score (possible total score 0-10): age ≥ 65 years (2 points); history of chronic obstructive pulmonary disease or obstructive sleep apnea (1 point); thyroid disease (1 point); NT-proBNP ≥ 250 pg/ml (2 points); left atrial enlargement (2 points); cortical topography of stroke, including hemispheric or cerebellar cortex (1 point); and intracranial large vessel occlusion (1 point). A score = 5 identified patients with paroxysmal AF with a sensitivity of 83% and a specificity of 80%. Screening for atrial fibrillation scale (SAFE) is a novel and simple strategy for selecting ischemic stroke patients at higher risk of having AF who can benefit from a more thorough etiological evaluation. External validation of SAFE in a multicenter study, with a larger number of patients, is warranted.
PB Frontiers Research Foundation
SN 1664-2295
YR 2022
FD 2022-05-19
LK http://hdl.handle.net/10668/20644
UL http://hdl.handle.net/10668/20644
LA en
NO Amaya Pascasio L, Quesada López M, García-Torrecillas JM, Arjona-Padillo A, Martínez Sánchez P. Development of a Score to Predict the Paroxysmal Atrial Fibrillation in Stroke Patients: The Screening for Atrial Fibrillation Scale. Front Neurol. 2022 Jun 28;13:900582.
NO The investigators were granted funds by the Carlos III Institute of Health (RICORS-ICTUS and RD21/0006/0010).
DS RISalud
RD Apr 18, 2025