RT Journal Article
T1 Association of Urinary Levels of Bisphenols A, F, and S with Endometriosis Risk: Preliminary Results of the EndEA Study.
A1 Peinado, Francisco M
A1 Lendinez, Inmaculada
A1 Sotelo, Rafael
A1 Iribarne-Duran, Luz M
A1 Fernandez-Parra, Jorge
A1 Vela-Soria, Fernando
A1 Olea, Nicolas
A1 Fernandez, Mariana F
A1 Freire, Carmen
A1 Leon, Josefa
A1 Perez-Cabrera, Beatriz
A1 Ocon-Hernandez, Olga
A1 Artacho-Cordon, Francisco
K1 bisphenol A
K1 bisphenol F
K1 bisphenol S
K1 endocrine disruption
K1 endometriosis
K1 oxidative stress
AB Aim: The aim of this study was to explore associations of urinary concentrations of bisphenols A (BPA), S (BPS), and F (BPF) and of thiobarbituric acid reactive substances (TBARS) with the risk of endometriosis in women of childbearing age. Methods: This case-control study enrolled 124 women between January 2018 and July 2019: 35 women with endometriosis (cases) and 89 women without endometriosis undergoing abdominal surgery for other reasons (controls). Endometriosis was diagnosed (cases) or ruled out (controls) by laparoscopic inspection of the pelvis and the biopsy of suspected lesions (histological diagnosis). Fasting urine samples were collected before surgery to determine concentrations of BPA, BPS, BPF, and TBARS. Associations of bisphenol and TBARS concentrations with endometriosis risk were explored with multivariate logistic and linear regression analyses. Results: After adjustment for urinary creatinine, age, BMI, parity, and residence, endometriosis risk was increased with each 1 log unit of BPA [OR 1.5; 95%CI 1.0-2.3] and Σbisphenols [OR 1.5; 95%CI 0.9-2.3] but was not associated with the presence of BPS and BPF. Classification of the women by tertiles of exposure revealed statistically significant associations between endometriosis risk and the second tertile of exposure to BPA [OR 3.7; 95%CI 1.3-10.3] and Σbisphenols [OR 5.4; 95%CI 1.9-15.6]. In addition, TBARS concentrations showed a close-to-significant relationship with increased endometriosis risk [OR 1.6; 95%CI 1.0-2.8], and classification by TBARS concentration tertile revealed that the association between endometriosis risk and concentrations of BPA [OR 2.0; 95%CI 1.0-4.1] and Σbisphenols [OR 2.2; 95%CI 1.0-4.6] was only statistically significant for women in the highest TBARS tertile (>4.23 μM). Conclusion: Exposure to bisphenols may increase the risk of endometriosis, and oxidative stress may play a crucial role in this association. Further studies are warranted to verify these findings.
PB MDPI AG
YR 2020
FD 2020-02-13
LK http://hdl.handle.net/10668/15123
UL http://hdl.handle.net/10668/15123
LA en
NO Peinado FM, Lendínez I, Sotelo R, Iribarne-Durán LM, Fernández-Parra J, Vela-Soria F,  et al. Association of Urinary Levels of Bisphenols A, F, and S with Endometriosis Risk: Preliminary Results of the EndEA Study. Int J Environ Res Public Health. 2020 Feb 13;17(4):1194.
NO Instituto de Salud Carlos III: PI17/01743; Instituto de Salud Carlos III: PI16/01820; Instituto de Salud Carlos III: PI16/01812; Instituto de Salud Carlos III: PI16/01858; Instituto de Salud Carlos III: PI17/01526; Instituto de Salud Carlos III: IFI18/00052; Instituto de Salud Carlos III: FI17/00316; Instituto de Salud Carlos III: INT18/00060; European Commission: H2020-EJP-HBM4EU.
DS RISalud
RD Apr 11, 2025