TY  - JOUR
AU  - Kosar, Martin
AU  - Giannattasio, Michele
AU  - Piccini, Daniele
AU  - Maya-Mendoza, Apolinar
AU  - García-Benítez, Francisco
AU  - Bartkova, Jirina
AU  - Barroso, Sonia I
AU  - Gaillard, Hélène
AU  - Martini, Emanuele
AU  - Restuccia, Umberto
AU  - Ramirez-Otero, Miguel Angel
AU  - Garre, Massimiliano
AU  - Verga, Eleonora
AU  - Andújar-Sánchez, Miguel
AU  - Maynard, Scott
AU  - Hodny, Zdenek
AU  - Costanzo, Vincenzo
AU  - Kumar, Amit
AU  - Bachi, Angela
AU  - Aguilera, Andrés
AU  - Bartek, Jiri
AU  - Foiani, Marco
PY  - 2021
DO  - 10.1038/s41467-021-24224-3
UR  - http://hdl.handle.net/10668/18040
T2  - Nature communications
AB  - Although human nucleoporin Tpr is frequently deregulated in cancer, its roles are poorly understood. Here we show that Tpr depletion generates transcription-dependent replication stress, DNA breaks, and genomic instability. DNA fiber assays and...
LA  - en
KW  - Acetyltransferases
KW  - Cell Survival
KW  - DNA Damage
KW  - DNA Replication
KW  - Genomic Instability
KW  - HeLa Cells
KW  - Humans
KW  - Intracellular Signaling Peptides and Proteins
KW  - Neoplasms
KW  - Nuclear Pore Complex Proteins
KW  - Protein Interaction Maps
KW  - Proto-Oncogene Proteins
KW  - RNA Transport
TI  - The human nucleoporin Tpr protects cells from RNA-mediated replication stress.
TY  - research article
VL  - 12
ER  -