RT Journal Article
T1 MNCD: A New Tool for Classifying Parkinson's Disease in Daily Clinical Practice.
A1 Santos Garcia, Diego
A1 Alvarez Sauco, Maria
A1 Calopa, Matilde
A1 Carrillo, Fatima
A1 Escamilla Sevilla, Francisco
A1 Freire, Eric
A1 Garcia Ramos, Rocio
A1 Kulisevsky, Jaime
A1 Gomez Esteban, Juan Carlos
A1 Legarda, Ines
A1 Luquin, Maria Rosario Isabel
A1 Castrillo, Juan Carlos Martinez
A1 Martinez-Martin, Pablo
A1 Martinez-Torres, Irene
A1 Mir, Pablo
A1 Ignacio, Angel Sesar
K1 Parkinson’s disease
K1 cognition
K1 dependency
K1 motor symptoms
K1 non-motor symptoms
AB Background and objective: Parkinson's disease (PD) is a clinically heterogeneous disorder in which the symptoms and prognosis can be very different among patients. We propose a new simple classification to identify key symptoms and staging in PD. Patients and Methods: Sixteen movement disorders specialists from Spain participated in this project. The classification was consensually approved after a discussion and review process from June to October 2021. The TNM classification and the National Institutes of Health Stroke Scale (NIHSS) were considered as models in the design. Results: The classification was named MNCD and included 4 major axes: (1) motor symptoms; (2) non-motor symptoms; (3) cognition; (4) dependency for activities of daily living (ADL). Motor axis included 4 sub-axes: (1) motor fluctuations; (2) dyskinesia; (3) axial symptoms; (4) tremor. Four other sub-axes were included in the non-motor axis: (1) neuropsychiatric symptoms; (2) autonomic dysfunction; (3) sleep disturbances and fatigue; (4) pain and sensory disorders. According to the MNCD, 5 stages were considered, from stage 1 (no disabling motor or non-motor symptoms with normal cognition and independency for ADL) to 5 (dementia and dependency for basic ADL). Conclusions: A new simple classification of PD is proposed. The MNCD classification includes 4 major axes and 5 stages to identify key symptoms and monitor the evolution of the disease in patients with PD. It is necessary to apply this proof of concept in a properly designed study.
PB MDPI AG
SN 2075-4418
YR 2021
FD 2021-12-23
LK http://hdl.handle.net/10668/20955
UL http://hdl.handle.net/10668/20955
LA en
NO Santos García D, Álvarez Sauco M, Calopa M, Carrillo F, Escamilla Sevilla F, Freire E, et al. MNCD: A New Tool for Classifying Parkinson's Disease in Daily Clinical Practice. Diagnostics (Basel). 2021 Dec 28;12(1):55.
DS RISalud
RD Apr 4, 2025