RT Journal Article
T1 MNCD: A New Tool for Classifying Parkinson's Disease in Daily Clinical Practice.
A1 Santos-Garcia, Diego
A1 Alvarez-Sauco, Maria
A1 Calopa, Matilde
A1 Carrillo, Fatima
A1 Escamilla-Sevilla, Francisco
A1 Freire, Eric
A1 Garcia-Ramos, Rocio
A1 Kulisevsky, Jaime
A1 Gomez-Esteban, Juan Carlos
A1 Legarda, Ines
A1 Luquin, Maria Rosario Isabel
A1 Martinez-Castrillo, Juan Carlos
A1 Martinez-Martin, Pablo
A1 Martinez-Torres, Irene
A1 Mir, Pablo
A1 Ignacio, Angel Sesar
K1 Parkinson’s disease
K1 cognition
K1 dependency
K1 motor symptoms
K1 non-motor symptoms
AB Background and objective: Parkinson's disease (PD) is a clinically heterogeneous disorder in which the symptoms and prognosis can be very different among patients. We propose a new simple classification to identify key symptoms and staging in PD. Patients and Methods: Sixteen movement disorders specialists from Spain participated in this project. The classification was consensually approved after a discussion and review process from June to October 2021. The TNM classification and the National Institutes of Health Stroke Scale (NIHSS) were considered as models in the design. Results: The classification was named MNCD and included 4 major axes: (1) motor symptoms; (2) non-motor symptoms; (3) cognition; (4) dependency for activities of daily living (ADL). Motor axis included 4 sub-axes: (1) motor fluctuations; (2) dyskinesia; (3) axial symptoms; (4) tremor. Four other sub-axes were included in the non-motor axis: (1) neuropsychiatric symptoms; (2) autonomic dysfunction; (3) sleep disturbances and fatigue; (4) pain and sensory disorders. According to the MNCD, 5 stages were considered, from stage 1 (no disabling motor or non-motor symptoms with normal cognition and independency for ADL) to 5 (dementia and dependency for basic ADL). Conclusions: A new simple classification of PD is proposed. The MNCD classification includes 4 major axes and 5 stages to identify key symptoms and monitor the evolution of the disease in patients with PD. It is necessary to apply this proof of concept in a properly designed study.
PB MDPI AG
SN 2075-4418
YR 2021
FD 2021-12-28
LK http://hdl.handle.net/10668/20955
UL http://hdl.handle.net/10668/20955
LA en
NO Santos García D, Álvarez Sauco M, Calopa M, Carrillo F, Escamilla Sevilla F, Freire E, et al. MNCD: A New Tool for Classifying Parkinson's Disease in Daily Clinical Practice. Diagnostics (Basel). 2021 Dec 28;12(1):55.
DS RISalud
RD Oct 26, 2025