%0 Journal Article
%A Santos Garcia, Diego
%A Alvarez Sauco, Maria
%A Calopa, Matilde
%A Carrillo, Fatima
%A Escamilla Sevilla, Francisco
%A Freire, Eric
%A Garcia Ramos, Rocio
%A Kulisevsky, Jaime
%A Gomez Esteban, Juan Carlos
%A Legarda, Ines
%A Luquin, Maria Rosario Isabel
%A Castrillo, Juan Carlos Martinez
%A Martinez-Martin, Pablo
%A Martinez-Torres, Irene
%A Mir, Pablo
%A Ignacio, Angel Sesar
%T MNCD: A New Tool for Classifying Parkinson's Disease in Daily Clinical Practice.
%D 2021
%@ 2075-4418
%U http://hdl.handle.net/10668/20955
%X Background and objective: Parkinson's disease (PD) is a clinically heterogeneous disorder in which the symptoms and prognosis can be very different among patients. We propose a new simple classification to identify key symptoms and staging in PD. Patients and Methods: Sixteen movement disorders specialists from Spain participated in this project. The classification was consensually approved after a discussion and review process from June to October 2021. The TNM classification and the National Institutes of Health Stroke Scale (NIHSS) were considered as models in the design. Results: The classification was named MNCD and included 4 major axes: (1) motor symptoms; (2) non-motor symptoms; (3) cognition; (4) dependency for activities of daily living (ADL). Motor axis included 4 sub-axes: (1) motor fluctuations; (2) dyskinesia; (3) axial symptoms; (4) tremor. Four other sub-axes were included in the non-motor axis: (1) neuropsychiatric symptoms; (2) autonomic dysfunction; (3) sleep disturbances and fatigue; (4) pain and sensory disorders. According to the MNCD, 5 stages were considered, from stage 1 (no disabling motor or non-motor symptoms with normal cognition and independency for ADL) to 5 (dementia and dependency for basic ADL). Conclusions: A new simple classification of PD is proposed. The MNCD classification includes 4 major axes and 5 stages to identify key symptoms and monitor the evolution of the disease in patients with PD. It is necessary to apply this proof of concept in a properly designed study.
%K Parkinson’s disease
%K cognition
%K dependency
%K motor symptoms
%K non-motor symptoms
%~