RT Journal Article
T1 Mobile health and supervised rehabilitation versus mobile health alone in breast cancer survivors: Randomized controlled trial.
A1 Lozano-Lozano, Mario
A1 Martin-Martin, Lydia
A1 Galiano-Castillo, Noelia
A1 Fernandez-Lao, Carolina
A1 Cantarero-Villanueva, Irene
A1 Lopez-Barajas, Isabel B
A1 Arroyo-Morales, Manuel
K1 Breast cancer
K1 Integral strategy
K1 Occupational therapy
K1 Rehabilitation
K1 mHealth
AB Survival rates in cancer are increasing exponentially, with a corresponding increase/influence in disability-adjusted life-years. Efforts should be made to explore the optimal balance between unsupervised/distance-based and supervised/onsite approaches to cancer care. This study aimed to compare the clinical efficacy of the BENECA mobile Health (mHealth) lifestyle application combined with a supervised rehabilitation program (BENECA and supervised rehabilitation) versus the BENECA mHealth lifestyle application alone on quality of life (QoL) and functional outcomes of breast cancer survivors. This randomized controlled trial included 80 survivors of breast cancer diagnosed at stage I-IIIA, who completed adjuvant therapy and were overweight or obese at diagnosis. Participants were randomly allocated (ratio 1:1, 3 waves) to BENECA mHealth and rehabilitation for 2months (n=40) or BENECA mHealth and usual care (BENECA mHealth alone; n=40). Participants completed a questionnaire at baseline (T1), 8-weeks post-intervention (T2) and 6-month follow-up (T3). The primary outcome was QoL assessed with the EORT QLQ-C30. Secondary outcomes included upper-limb functionality and body composition. Statistical (between-group analyses of covariance) and clinical effects were analyzed by intention to treat. Both groups showed improved outcomes, but global QoL was significantly better with BENECA mHealth and rehabilitation than BENECA mHealth alone (mean difference, 12.76; 95% confidence interval 4.85; 20.67; P=0.004), with a moderate-to-large effect size (d=72). The proportion of participants reporting reliable clinical improvement on global QoL at T2 was higher with BENECA mHealth and rehabilitation than BENECA mHealth alone (57.5% vs 26.3%, P=0.008). Improvement in subjective and objective upper-limb functionality was also higher with BENECA mHealth and rehabilitation. The BENECA mHealth lifestyle application with a supervised rehabilitation program had a statistically and clinically significant effect on QoL and upper-limb functionality in breast cancer survivors and is a unique and important promising new approach.
PB Elsevier Masson
YR 2019
FD 2019-07-29
LK http://hdl.handle.net/10668/14450
UL http://hdl.handle.net/10668/14450
LA en
NO Lozano-Lozano M, Martín-Martín L, Galiano-Castillo N, Fernández-Lao C, Cantarero-Villanueva I, López-Barajas IB, et al. Mobile health and supervised rehabilitation versus mobile health alone in breast cancer survivors: Randomized controlled trial. Ann Phys Rehabil Med. 2020 Jul;63(4):316-324.
NO The study was funded by the Spanish Ministry of Economy and Competitiveness (Plan Estatal de I+D+I 2013–2016), Fondo de Investigación Sanitaria del Instituto de Salud Carlos III (PI14/01627), and Fondos Estructurales de la Unión Europea (FEDER). Additional support was provided by the Spanish Ministry of Education (FPU14/01069) and the University of Granada through the Plan Propio de Investigación 2016, Excellence Actions: Units of Excellence, and the Unit of Excellence on Exercise and Health (UCEES). This work was part of a Ph.D. thesis conducted in the Clinical Medicine and Public Health Doctoral Studies of the University of Granada, Spain.
DS RISalud
RD Apr 19, 2025