RT Journal Article
T1 Pre- and perinatal complications in relation to Tourette syndrome and co-occurring obsessive-compulsive disorder and attention-deficit/hyperactivity disorder.
A1 Abdulkadir, Mohamed
A1 Tischfield, Jay A
A1 King, Robert A
A1 Fernandez, Thomas V
A1 Brown, Lawrence W
A1 Cheon, Keun-Ah
A1 Coffey, Barbara J
A1 de Bruijn, Sebastian F T M
A1 Elzerman, Lonneke
A1 Garcia-Delgar, Blanca
A1 Gilbert, Donald L
A1 Grice, Dorothy E
A1 Hagstrøm, Julie
A1 Hedderly, Tammy
A1 Heyman, Isobel
A1 Hong, Hyun Ju
A1 Huyser, Chaim
A1 Ibanez-Gomez, Laura
A1 Kim, Young Key
A1 Kim, Young-Shin
A1 Koh, Yun-Joo
A1 Kook, Sodahm
A1 Kuperman, Samuel
A1 Lamerz, Andreas
A1 Leventhal, Bennett
A1 Ludolph, Andrea G
A1 Madruga-Garrido, Marcos
A1 Maras, Athanasios
A1 Messchendorp, Marieke D
A1 Mir, Pablo
A1 Morer, Astrid
A1 Münchau, Alexander
A1 Murphy, Tara L
A1 Openneer, Thaïra J C
A1 Plessen, Kerstin J
A1 Rath, Judith J G
A1 Roessner, Veit
A1 Fründt, Odette
A1 Shin, Eun-Young
A1 Sival, Deborah A
A1 Song, Dong-Ho
A1 Song, Jungeun
A1 Stolte, Anne-Marie
A1 Tübing, Jennifer
A1 van den Ban, Els
A1 Visscher, Frank
A1 Wanderer, Sina
A1 Woods, Martin
A1 Zinner, Samuel H
A1 State, Matthew W
A1 Heiman, Gary A
A1 Hoekstra, Pieter J
A1 Dietrich, Andrea
K1 Attention-deficit hyperactivity disorder
K1 Delivery
K1 Obsessive-compulsive disorder
K1 Pregnancy
K1 Prenatal
K1 Tourette syndrome
AB Pre- and perinatal complications have been implicated in the onset and clinical expression of Tourette syndrome albeit with considerable inconsistencies across studies. Also, little is known about their role in co-occurring obsessive-compulsive disorder (OCD) and attention-deficit/hyperactivity disorder (ADHD) in individuals with a tic disorder. Therefore, we aimed to investigate the role of pre- and perinatal complications in relation to the presence and symptom severity of chronic tic disorder and co-occurring OCD and ADHD using data of 1113 participants from the Tourette International Collaborative Genetics study. This study included 586 participants with a chronic tic disorder and 527 unaffected family controls. We controlled for age and sex differences by creating propensity score matched subsamples for both case-control and within-case analyses. We found that premature birth (OR = 1.72) and morning sickness requiring medical attention (OR = 2.57) were associated with the presence of a chronic tic disorder. Also, the total number of pre- and perinatal complications was higher in those with a tic disorder (OR = 1.07). Furthermore, neonatal complications were related to the presence (OR = 1.46) and severity (b = 2.27) of co-occurring OCD and also to ADHD severity (b = 1.09). Delivery complications were only related to co-occurring OCD (OR = 1.49). We conclude that early exposure to adverse situations during pregnancy is related to the presence of chronic tic disorders. Exposure at a later stage, at birth or during the first weeks of life, appears to be associated with co-occurring OCD and ADHD.
YR 2016
FD 2016-07-22
LK http://hdl.handle.net/10668/10341
UL http://hdl.handle.net/10668/10341
LA en
DS RISalud
RD Apr 5, 2025