RT Journal Article
T1 Prosthetic Shoulder Joint Infection by Cutibacterium acnes: Does Rifampin Improve Prognosis? A Retrospective, Multicenter, Observational Study.
A1 Vilchez, Helem H
A1 Escudero-Sanchez, Rosa
A1 Fernandez-Sampedro, Marta
A1 Murillo, Oscar
A1 Auñón, Álvaro
A1 Rodríguez-Pardo, Dolors
A1 Jover-Sáenz, Alfredo
A1 Del Toro, Mª Dolores
A1 Rico, Alicia
A1 Falgueras, Luis
A1 Praena-Segovia, Julia
A1 Guío, Laura
A1 Iribarren, José A
A1 Lora-Tamayo, Jaime
A1 Benito, Natividad
A1 Morata, Laura
A1 Ramirez, Antonio
A1 Riera, Melchor
A1 Study Group On Osteoarticular Infections Geio, 
A1 The Spanish Network For Research In Infectious Pathology Reipi, 
K1 Cutibacterium acnes
K1 prosthetic joint infection
K1 surgical and medical treatment
AB This retrospective, multicenter observational study aimed to describe the outcomes of surgical and medical treatment of C. acnes-related prosthetic joint infection (PJI) and the potential benefit of rifampin-based therapies. Patients with C. acnes-related PJI who were diagnosed and treated between January 2003 and December 2016 were included. We analyzed 44 patients with C. acnes-related PJI (median age, 67.5 years (IQR, 57.3-75.8)); 75% were men. The majority (61.4%) had late chronic infection according to the Tsukayama classification. All patients received surgical treatment, and most antibiotic regimens (43.2%) included β-lactam. Thirty-four patients (87.17%) were cured; five showed relapse. The final outcome (cure vs. relapse) showed a nonsignificant trend toward higher failure frequency among patients with previous prosthesis (OR: 6.89; 95% CI: 0.80-58.90) or prior surgery and infection (OR: 10.67; 95% IC: 1.08-105.28) in the same joint. Patients treated with clindamycin alone had a higher recurrence rate (40.0% vs. 8.8%). Rifampin treatment did not decrease recurrence in patients treated with β-lactams. Prior prosthesis, surgery, or infection in the same joint might be related to recurrence, and rifampin-based combinations do not seem to improve prognosis. Debridement and implant retention appear a safe option for surgical treatment of early PJI.
SN 2079-6382
YR 2021
FD 2021-04-21
LK http://hdl.handle.net/10668/17675
UL http://hdl.handle.net/10668/17675
LA en
DS RISalud
RD Apr 7, 2025