%0 Journal Article
%A Vilchez, Helem H
%A Escudero-Sanchez, Rosa
%A Fernandez-Sampedro, Marta
%A Murillo, Oscar
%A Auñón, Álvaro
%A Rodríguez-Pardo, Dolors
%A Jover-Sáenz, Alfredo
%A Del Toro, Mª Dolores
%A Rico, Alicia
%A Falgueras, Luis
%A Praena-Segovia, Julia
%A Guío, Laura
%A Iribarren, José A
%A Lora-Tamayo, Jaime
%A Benito, Natividad
%A Morata, Laura
%A Ramirez, Antonio
%A Riera, Melchor
%A Study Group On Osteoarticular Infections Geio,
%A The Spanish Network For Research In Infectious Pathology Reipi,
%T Prosthetic Shoulder Joint Infection by Cutibacterium acnes: Does Rifampin Improve Prognosis? A Retrospective, Multicenter, Observational Study.
%D 2021
%@ 2079-6382
%U http://hdl.handle.net/10668/17675
%X This retrospective, multicenter observational study aimed to describe the outcomes of surgical and medical treatment of C. acnes-related prosthetic joint infection (PJI) and the potential benefit of rifampin-based therapies. Patients with C. acnes-related PJI who were diagnosed and treated between January 2003 and December 2016 were included. We analyzed 44 patients with C. acnes-related PJI (median age, 67.5 years (IQR, 57.3-75.8)); 75% were men. The majority (61.4%) had late chronic infection according to the Tsukayama classification. All patients received surgical treatment, and most antibiotic regimens (43.2%) included β-lactam. Thirty-four patients (87.17%) were cured; five showed relapse. The final outcome (cure vs. relapse) showed a nonsignificant trend toward higher failure frequency among patients with previous prosthesis (OR: 6.89; 95% CI: 0.80-58.90) or prior surgery and infection (OR: 10.67; 95% IC: 1.08-105.28) in the same joint. Patients treated with clindamycin alone had a higher recurrence rate (40.0% vs. 8.8%). Rifampin treatment did not decrease recurrence in patients treated with β-lactams. Prior prosthesis, surgery, or infection in the same joint might be related to recurrence, and rifampin-based combinations do not seem to improve prognosis. Debridement and implant retention appear a safe option for surgical treatment of early PJI.
%K Cutibacterium acnes
%K prosthetic joint infection
%K surgical and medical treatment
%~