RT Journal Article
T1 Externally-Controlled Systems for Immunotherapy: From Bench to Bedside
A1 Tristán-Manzano, María
A1 Justicia-Lirio, Pedro
A1 Maldonado-Pérez, Noelia
A1 Cortijo-Gutiérrez, Marina
A1 Benabdellah, Karim
A1 Martin, Francisco
K1 Immunotherapy
K1 Gene therapy
K1 Externally controlled
K1 Inducible
K1 ATMPs
K1 Transgene expression
K1 Cancer
K1 Autoimmunity
K1 Inmunoterapia
K1 Terapia genética
K1 Transgenes
K1 Neoplasias
K1 Autoinmunidad
AB Immunotherapy is a very promising therapeutic approach against cancer that is particularly effective when combined with gene therapy. Immuno-gene therapy approaches have led to the approval of four advanced therapy medicinal products (ATMPs) for the treatment of p53-deficient tumors (Gendicine and Imlygic), refractory acute lymphoblastic leukemia (Kymriah) and large B-cell lymphomas (Yescarta). In spite of these remarkable successes, immunotherapy is still associated with severe side effects for CD19+ malignancies and is inefficient for solid tumors. Controlling transgene expression through an externally administered inductor is envisioned as a potent strategy to improve safety and efficacy of immunotherapy. The aim is to develop smart immunogene therapy-based-ATMPs, which can be controlled by the addition of innocuous drugs or agents, allowing the clinicians to manage the intensity and durability of the therapy. In the present manuscript, we will review the different inducible, versatile and externally controlled gene delivery systems that have been developed and their applications to the field of immunotherapy. We will highlight the advantages and disadvantages of each system and their potential applications in clinics.
PB Frontiers
YR 2020
FD 2020-09-04
LK http://hdl.handle.net/10668/3707
UL http://hdl.handle.net/10668/3707
LA en
NO Tristán-Manzano M, Justicia-Lirio P, Maldonado-Pérez N, Cortijo-Gutiérrez M, Benabdellah K, Martin F. Externally-Controlled Systems for Immunotherapy: From Bench to Bedside. Front Immunol. 2020 Sep 4;11:2044
DS RISalud
RD Apr 9, 2025