RT Journal Article
T1 Leptin levels were negatively associated with lumbar spine bone mineral content in children with overweight or obesity.
A1 Gil-Cosano, Jose J
A1 Gracia-Marco, Luis
A1 Ubago-Guisado, Esther
A1 Migueles, Jairo H
A1 Courteix, Daniel
A1 Labayen, Idoia
A1 Plaza-Florido, Abel
A1 Molina-Garcia, Pablo
A1 Dutheil, Frederic
A1 Ortega, Francisco B
K1 adipokines
K1 bone
K1 muscle strength
K1 obesity
K1 prepubertal
AB Adipokines seem to play a role in bone morphogenesis, although this also depends on the mechanical forces applied to the skeleton. The aim was to assess the relationships of resting leptin and adiponectin with bone parameters and whether high muscular fitness levels affect these relationships in children with overweight or obesity. This cross-sectional study took part from 2014 to 2016 in Granada, Spain. Participants were recruited from University Hospitals, and we also used advertisements in local media and school contacts in the city. Adipokines were analysed in plasma. Muscular fitness was assessed by one repetition maximum in bench and leg press tests. Dual-energy X-ray absorptiometry was used to measure bone parameters. We included 84 children (10.0 ± 1.2y; 63% boys) in this analysis. Leptin was negatively associated with lumbar spine bone mineral content (β = -0.162, p = 0.053). No significant interaction was found for muscular fitness. Simple slope estimates suggested that children performing more than 133.3 kg in leg press test ameliorated the negative association between leptin and lumbar spine bone mineral content. Leptin levels were negatively associated with lumbar spine bone mineral content in children with overweight or obesity. A high muscular fitness at the lower body could counteract this association.
PB Wiley-Blackwell Publishing Ltd.
YR 2022
FD 2022-06-22
LK http://hdl.handle.net/10668/19911
UL http://hdl.handle.net/10668/19911
LA en
NO Gil-Cosano JJ, Gracia-Marco L, Ubago-Guisado E, Migueles JH, Courteix D, Labayen I, et al. Leptin levels were negatively associated with lumbar spine bone mineral content in children with overweight or obesity. Acta Paediatr. 2022 Oct;111(10):1966-1973.
NO This study was mainly supported by grantsfrom the Spanish Ministry of Economyand Competitiveness (DEP2013-47540,DEP2016-79512-R, DEP2017-91544-EXP and RYC-2011-09011), EuropeanRegional Development Fund (ERDF) ofthe European Commission (No 667302)and the Alicia Koplowitz Foundation.Additional funding was obtained fromthe Andalusian Operational Programmesupported with ERDF (FEDER in Spanish, B-CTS-355-UGR18). Additional supportwas obtained from University of Granada,Plan Propio de Investigación 2016,Excellence actions: Units of Excellence,Unit of Excellence on Exercise and Health,the Junta de Andalucía, Consejeríade Conocimiento, Investigación yUniversidades (SOMM17/6107/UGR);the EXERNET Research Network onExercise and Health in Special populations(DEP2005-00046/ACTI); and theHL-PIVOT network - Healthy Living forPandemic Event Protection. Fundingfor open access charge: Universidad deGranada / CBUA.
DS RISalud
RD Apr 11, 2025