RT Journal Article
T1 Pregnancy Outcomes and SARS-CoV-2 Infection: The Spanish Obstetric Emergency Group Study.
A1 Cruz-Melguizo, Sara
A1 de-la-Cruz-Conty, Maria Luisa
A1 Carmona-Payan, Paola
A1 Abascal-Saiz, Alejandra
A1 Pintando-Recarte, Pilar
A1 Gonzalez-Rodriguez, Laura
A1 Cuenca-Marin, Celia
A1 Martinez-Varea, Alicia
A1 Oreja-Cuesta, Ana Belen
A1 Prats-Rodriguez, Pilar
A1 Fernandez-Buhigas, Irene
A1 Rodriguez-Gallego, Maria Victoria
A1 Fernandez-Alonso, Ana Maria
A1 Lopez-Perez, Rocio
A1 Broullon-Molanes, Jose Roman
A1 Encinas-Pardilla, Maria Begoña
A1 Ramirez-Gomez, Mercedes
A1 Gimeno-Gimeno, Maria Joaquina
A1 Sanchez-Muñoz, Antonio
A1 Martinez-Perez, Oscar
K1 COVID-19
K1 SARS-CoV-2
K1 Coronavirus
K1 Delivery
K1 Maternal complications
K1 Perinatal outcomes
K1 Pregnancy
K1 Premature birth
AB Pregnant women who are infected with SARS-CoV-2 are at an increased risk of adverse perinatal outcomes. With this study, we aimed to better understand the relationship between maternal infection and perinatal outcomes, especially preterm births, and the underlying medical and interventionist factors. This was a prospective observational study carried out in 78 centers (Spanish Obstetric Emergency Group) with a cohort of 1347 SARS-CoV-2 PCR-positive pregnant women registered consecutively between 26 February and 5 November 2020, and a concurrent sample of PCR-negative mothers. The patients' information was collected from their medical records, and the association of SARS-CoV-2 and perinatal outcomes was evaluated by univariable and multivariate analyses. The data from 1347 SARS-CoV-2-positive pregnancies were compared with those from 1607 SARS-CoV-2-negative pregnancies. Differences were observed between both groups in premature rupture of membranes (15.5% vs. 11.1%, p< 0.001); venous thrombotic events (1.5% vs. 0.2%, p <0.001); and severe pre-eclampsia incidence (40.6 vs. 15.6%, p = 0.001), which could have been overestimated in the infected cohort due to the shared analytical signs between this hypertensive disorder and COVID-19. In addition, more preterm deliveries were observed in infected patients (11.1% vs. 5.8%, p < 0.001) mainly due to an increase in iatrogenic preterm births. The prematurity in SARS-CoV-2-affected pregnancies results from a predisposition to end the pregnancy because of maternal disease (pneumonia and pre-eclampsia, with or without COVID-19 symptoms).
PB MDPI
YR 2021
FD 2021-05-07
LK http://hdl.handle.net/10668/17897
UL http://hdl.handle.net/10668/17897
LA en
NO Cruz Melguizo S, de la Cruz Conty ML, Carmona Payán P, Abascal-Saiz A, Pintando Recarte P, González Rodríguez L, et al. Pregnancy Outcomes and SARS-CoV-2 Infection: The Spanish Obstetric Emergency Group Study. Viruses. 2021 May 7;13(5):853
DS RISalud
RD Jun 1, 2025