RT Journal Article
T1 Hypoxia Tolerant Species: The Wisdom of Nature Translated into Targets for Stroke Therapy
A1 del Río, Carmen
A1 Montaner, Joan
K1 Stroke
K1 Neuroprotection
K1 Hypoxia tolerance
K1 Stroke therapy
K1 Cell death
K1 Ischemia
K1 Accidente cerebrovascular
K1 Neuroprotección
K1 Hipoxia
K1 Muerte celular
K1 Isquemia
AB Human neurons rapidly die after ischemia and current therapies for stroke management are limited to restoration of blood flow to prevent further brain damage. Thrombolytics and mechanical thrombectomy are the available reperfusion treatments, but most of the patients remain untreated. Neuroprotective therapies focused on treating the pathogenic cascade of the disease have widely failed. However, many animal species demonstrate that neurons can survive the lack of oxygen for extended periods of time. Here, we reviewed the physiological and molecular pathways inherent to tolerant species that have been described to contribute to hypoxia tolerance. Among them, Foxo3 and Eif5A were reported to mediate anoxic survival in Drosophila and Caenorhabditis elegans, respectively, and those results were confirmed in experimental models of stroke. In humans however, the multiple mechanisms involved in brain cell death after a stroke causes translation difficulties to arise making necessary a timely and coordinated control of the pathological changes. We propose here that, if we were able to plagiarize such natural hypoxia tolerance through drugs combined in a pharmacological cocktail it would open new therapeutic opportunities for stroke and likely, for other hypoxic conditions.
PB MDPI
SN 1661-6596
YR 2021
FD 2021-10-15
LK http://hdl.handle.net/10668/4141
UL http://hdl.handle.net/10668/4141
LA en
NO Del Río C, Montaner J. Hypoxia Tolerant Species: The Wisdom of Nature Translated into Targets for Stroke Therapy. Int J Mol Sci. 2021 Oct 15;22(20):11131
DS RISalud
RD Apr 7, 2025