RT Journal Article
T1 Tratamiento con hormona de crecimiento en pequeños para la edad gestacional en España
T2 [Growth hormone treatment in small for gestational age children in Spain].
A1 Rial-Rodriguez, Jose Manuel
A1 de-Arriba-Muñoz, Antonio
A1 Bosch-Muñoz, Jordi
A1 Cabanas-Rodriguez, Paloma
A1 Cañete-Estrada, Ramon
A1 Diez-Lopez, Ignacio
A1 Hawkins-Solis, Maria Magdalena
A1 Martinez-Aedo Ollero, María Jose
A1 Rodriguez-Dehli, Ana Cristina
A1 Ibañez-Toda, Lourdes
K1 Growth hormone
K1 Hormona de crecimiento
K1 Hospitales públicos
K1 Pequeño para la edad gestacional
K1 Public hospitals
K1 Respuesta terapéutica
K1 Small for gestational age
K1 Treatment outcome
AB Since its approval by the European Medicines Agency, a great number of patients born small for gestational date have received recombinant growth hormone treatment in Spain. The aim of this study is to analyse its outcome in the setting of ordinary clinical practice. Information was gathered from the registers of the assessment boards that authorise all growth hormone treatments prescribed in public hospitals in six autonomic communities (regions). Valid data from 974 patients was obtained. All of them complied with criteria established by the European Medicines Agency. Patients in the sample were smaller in length than weight at birth, with their median target height being below 1 standard deviation (SD), and 23% of them had been delivered prematurely. Treatment was started at 7.2±2.8 years (mean±SD). The mean patient height at start was -3.1±0.8 SD. They gained 0.7±0.2 SD in the first year, and 1.2±0.8 SD after two years. Final height was attained by 8% of the sample, reaching -1.4±0.7 SD. These results are similar to other Spanish and international published studies, and are representative of the current practice in Spain. Despite treatment being started at a late age, adequate growth is observed in the short term and in the final height. Up to a 24% of patients show a poor response in the first year.
PB Elsevier Doyma
YR 2016
FD 2016-04-12
LK http://hdl.handle.net/10668/10086
UL http://hdl.handle.net/10668/10086
LA es
NO Rial Rodríguez JM, de Arriba Muñoz A, Bosch Muñoz J, Cabanas Rodríguez P, Cañete Estrada R, Díez López I, et al. Tratamiento con hormona de crecimiento en pequeños para la edad gestacional en España. An Pediatr (Barc). 2017 May;86(5):249-254.
DS RISalud
RD Apr 9, 2025