RT Journal Article
T1 Iron-Gold Nanoflowers: A Promising Tool for Multimodal Imaging and Hyperthermia Therapy.
A1 Christou, Evangelia
A1 Pearson, John R
A1 Beltrán, Ana M
A1 Fernández-Afonso, Yilian
A1 Gutiérrez, Lucía
A1 de la Fuente, Jesús M
A1 Gámez, Francisco
A1 García-Martín, María L
A1 Caro, Carlos
K1 CT
K1 MRI
K1 gold–iron nanoparticles
K1 magnetic hyperthermia
K1 multimodal imaging
K1 nanoflowers
K1 photothermal therapy
AB The development of nanoplatforms prepared to perform both multimodal imaging and combined therapies in a single entity is a fast-growing field. These systems are able to improve diagnostic accuracy and therapy success. Multicomponent Nanoparticles (MCNPs), composed of iron oxide and gold, offer new opportunities for Magnetic Resonance Imaging (MRI) and Computed Tomography (CT) diagnosis, as well as combined therapies based on Magnetic Hyperthermia (MH) and Photothermal Therapy (PT). In this work, we describe a new seed-assisted method for the synthesis of Au@Fe Nanoparticles (NPs) with a flower-like structure. For biomedical purposes, Au@Fe NPs were functionalized with a PEGylated ligand, leading to high colloidal stability. Moreover, the as-obtained Au@Fe-PEG NPs exhibited excellent features as both MRI and CT Contrast Agents (CAs), with high r2 relaxivity (60.5 mM-1⋅s-1) and X-ray attenuation properties (8.8 HU mM-1⋅HU). In addition, these nanoflowers presented considerable energy-to-heat conversion under both Alternating Magnetic Fields (AMFs) (∆T ≈ 2.5 °C) and Near-Infrared (NIR) light (∆T ≈ 17 °C). Finally, Au@Fe-PEG NPs exhibited very low cytotoxicity, confirming their potential for theranostics applications.
SN 1999-4923
YR 2022
FD 2022-03-14
LK http://hdl.handle.net/10668/21546
UL http://hdl.handle.net/10668/21546
LA en
DS RISalud
RD Apr 6, 2025