RT Journal Article
T1 Plasma Ceramides, Mediterranean Diet, and Incident Cardiovascular Disease in the PREDIMED Trial (Prevención con Dieta Mediterránea).
A1 Wang, Dong D
A1 Toledo, Estefanía
A1 Hruby, Adela
A1 Rosner, Bernard A
A1 Willett, Walter C
A1 Sun, Qi
A1 Razquin, Cristina
A1 Zheng, Yan
A1 Ruiz-Canela, Miguel
A1 Guasch-Ferré, Marta
A1 Corella, Dolores
A1 Gómez-Gracia, Enrique
A1 Fiol, Miquel
A1 Estruch, Ramón
A1 Ros, Emilio
A1 Lapetra, José
A1 Fito, Montserrat
A1 Aros, Fernando
A1 Serra-Majem, Luis
A1 Lee, Chih-Hao
A1 Clish, Clary B
A1 Liang, Liming
A1 Salas-Salvadó, Jordi
A1 Martínez-González, Miguel A
A1 Hu, Frank B
K1 Mediterranean diet
K1 cardiovascular disease
K1 ceramide
K1 coronary heart disease
K1 stroke
AB Although in vitro studies and investigations in animal models and small clinical populations have suggested that ceramides may represent an intermediate link between overnutrition and certain pathological mechanisms underlying cardiovascular disease (CVD), no prospective studies have investigated the association between plasma ceramides and risk of CVD. The study population consisted of 980 participants from the PREDIMED trial (Prevención con Dieta Mediterránea), including 230 incident cases of CVD and 787 randomly selected participants at baseline (including 37 overlapping cases) followed for ≤7.4 years. Participants were randomized to a Mediterranean diet supplemented with extra virgin olive oil, a Mediterranean diet supplemented with nuts, or a control diet. Plasma ceramide concentrations were measured on a liquid chromatography tandem mass spectrometry metabolomics platform. The primary outcome was a composite of nonfatal acute myocardial infarction, nonfatal stroke, or cardiovascular death. Hazard ratios were estimated with weighted Cox regression models using Barlow weights to account for the case-cohort design. The multivariable hazard ratios (HR) and 95% confidence intervals (CIs) comparing the extreme quartiles of plasma concentrations of C16:0, C22:0, C24:0, and C24:1 ceramides were 2.39 (1.49-3.83, Ptrend Our study documented a novel positive association between baseline plasma ceramide concentrations and incident CVD. In addition, a Mediterranean dietary intervention may mitigate potential deleterious effects of elevated plasma ceramide concentrations on CVD. URL: http://www.isrctn.com. Unique identifier: ISRCTN35739639.
YR 2017
FD 2017-03-09
LK http://hdl.handle.net/10668/10953
UL http://hdl.handle.net/10668/10953
LA en
DS RISalud
RD Apr 7, 2025