RT Journal Article
T1 Correlation between urinary and serum NT-proBNP in acute bronchiolitis: A pilot study.
A1 Rodriguez-Gonzalez, Moises
A1 Castellano-Martinez, Ana
A1 Estalella-Mendoza, Ana
A1 Rodriguez-Campoy, Patricia
A1 Estepa-Pedregosa, Lorena
A1 Calero-Ruiz, Maria Mercedes
A1 Saez-Benito Godino, Ana
A1 Flores-Gonzalez, Jose Carlos
K1 TB
K1 Acute bronchiolitis
K1 Biomarkers
K1 Infections: pneumonia
K1 Myocardial strain
K1 Natriuretic peptides
K1 Pulmonary hypertension
K1 Urinary NT-proBNP
K1 Viral
AB We aimed to analyze the correlation of urinary with serum N-terminal pro-brain natriuretic peptide (NT-proBNP) concentrations and its association with severity in acute bronchiolitis. A pilot observational study was conducted between October 1, 2021 and March 31, 2022 including acute bronchiolitis cases who attended our institution. Serum and urinary NT-proBNP concentrations were determined using the Alere i NT-proBNP assay in time-matched urine and blood samples. The Mann-Whitney U test, Spearman's correlations, and simple linear regression were utilized to analyze the association of urine NT-proBNP levels with serum NT-proBNP and with variables indicative of severe bronchiolitis. Seventeen infants (median age 68 [IQR: 36-91] days) with 36 time-matched samples were included. The urine NT-proBNP was positively and strongly correlated with the serum NT-proBNP concentrations (Spearman's ρ = 0.81 & R2  coefficient = 0.751; p  The urinary NT-proBNP concentrations could be a reliable surrogate for serum NT-proBNP levels and resulted elevated in cases of acute bronchiolitis with complicated evolution, suggesting a potential as a noninvasive tool to assess severity in this setting.
PB Wiley
YR 2022
FD 2022-10-22
LK http://hdl.handle.net/10668/22495
UL http://hdl.handle.net/10668/22495
LA en
NO Rodríguez-González M, Castellano-Martínez A, Estalella-Mendoza A, Rodríguez-Campoy P, Estepa-Pedregosa L, Calero-Ruiz MM, et al.  Correlation between urinary and serum NT-proBNP in acute bronchiolitis: A pilot study. Pediatr Pulmonol. 2023 Feb;58(2):492-499
DS RISalud
RD Apr 5, 2025