%0 Journal Article
%A Rodriguez-Gonzalez, Moises
%A Castellano-Martinez, Ana
%A Estalella-Mendoza, Ana
%A Rodriguez-Campoy, Patricia
%A Estepa-Pedregosa, Lorena
%A Calero-Ruiz, Maria Mercedes
%A Saez-Benito Godino, Ana
%A Flores-Gonzalez, Jose Carlos
%T Correlation between urinary and serum NT-proBNP in acute bronchiolitis: A pilot study.
%D 2022
%U http://hdl.handle.net/10668/22495
%X We aimed to analyze the correlation of urinary with serum N-terminal pro-brain natriuretic peptide (NT-proBNP) concentrations and its association with severity in acute bronchiolitis. A pilot observational study was conducted between October 1, 2021 and March 31, 2022 including acute bronchiolitis cases who attended our institution. Serum and urinary NT-proBNP concentrations were determined using the Alere i NT-proBNP assay in time-matched urine and blood samples. The Mann-Whitney U test, Spearman's correlations, and simple linear regression were utilized to analyze the association of urine NT-proBNP levels with serum NT-proBNP and with variables indicative of severe bronchiolitis. Seventeen infants (median age 68 [IQR: 36-91] days) with 36 time-matched samples were included. The urine NT-proBNP was positively and strongly correlated with the serum NT-proBNP concentrations (Spearman's ρ = 0.81 & R2  coefficient = 0.751; p  The urinary NT-proBNP concentrations could be a reliable surrogate for serum NT-proBNP levels and resulted elevated in cases of acute bronchiolitis with complicated evolution, suggesting a potential as a noninvasive tool to assess severity in this setting.
%K TB
%K Acute bronchiolitis
%K Biomarkers
%K Infections: pneumonia
%K Myocardial strain
%K Natriuretic peptides
%K Pulmonary hypertension
%K Urinary NT-proBNP
%K Viral
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