RT Journal Article
T1 Efficacy and Safety of a Novel Submucosal Injection Solution for Resection of Gastrointestinal Lesions.
A1 Moles-Aranda, Cristina
A1 González-Pérez, Raquel
A1 Gallego-Rojo, Francisco Javier
A1 Martínez-Augustin, Olga
A1 Clares-Naveros, Beatriz
A1 Sánchez de Medina, Fermín
A1 Morales-Molina, José Antonio
K1 efficacy
K1 endoscopic mucosal resection
K1 endoscopic submucosal dissection
K1 gastrointestinal endoscopy
K1 safety
K1 submucosal injection
AB Endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD) are minimally invasive and efficient techniques for the removal of gastrointestinal (GI) mucosal polyps. In both techniques, submucosal injection solutions are necessary for complete effectiveness and safety during the intervention to be obtained. The main objective of this study was to evaluate the efficacy and safety of a new sterile submucosal injection solution for EMR/ESD used within a clinical protocol in patients with intestinal polyps. We carried out a prospective study between 2016 and 2017 with patients who attended the Endoscopy Consultation-Digestive Department of Primary Hospital. Patients were selected for EMR/ESD after the application of clinical protocols. Thirty-six patients were selected (≥ 66 years with comorbidities and risk factors). Lesions were located mainly in the colon. Our solution presented an intestinal lift ≥ 60 min in EMR/ESD and a high expansion of tissue, optimum viscosity, and subsequent complete resorption. The genes S100A9 and TP53 presented an expression increase in the distal regions. TP53 and PCNA were the only genes whose expression was increased in polyp specimens vs. the surrounding tissue at the mRNA level. In EMR/ESD, our solution presented a prolonged effect at the intestinal level during all times of the intervention. Thus, our solution seems be an effective and safe alternative in cases of flat lesions in both techniques.
SN 2077-0383
YR 2020
FD 2020-04-18
LK https://hdl.handle.net/10668/28149
UL https://hdl.handle.net/10668/28149
LA en
DS RISalud
RD Apr 17, 2025