%0 Journal Article
%A Nimptsch, Katharina
%A Aleksandrova, Krasimira
%A Fedirko, Veronika
%A Jenab, Mazda
%A Gunter, Marc J
%A Siersema, Peter D
%A Wu, Kana
%A Katzke, Verena
%A Kaaks, Rudolf
%A Panico, Salvatore
%A Palli, Domenico
%A May, Anne M
%A Sieri, Sabina
%A Bueno-de-Mesquita, Bas
%A Standahl, Karina
%A Sanchez-Perez, Maria-Jose
%A Perez-Cornago, Aurora
%A Olsen, Anja
%A Tjønneland, Anne
%A Bonet, Catalina Bonet
%A Dahm, Christina C
%A Chirlaque, María-Dolores
%A Fiano, Valentina
%A Tumino, Rosario
%A Gurrea, Aurelio Barricarte
%A Boutron-Ruault, Marie-Christine
%A Menegaux, Florence
%A Severi, Gianluca
%A van Guelpen, Bethany
%A Lee, Young-Ae
%A Pischon, Tobias
%T Pre-diagnostic C-reactive protein concentrations, CRP genetic variation and mortality among individuals with colorectal cancer in Western European populations.
%D 2022
%U http://hdl.handle.net/10668/20281
%X The role of elevated pre-diagnostic C-reactive protein (CRP) concentrations on mortality in individuals with colorectal cancer (CRC) remains unclear. We investigated the association between pre-diagnostic high-sensitivity CRP concentrations and CRP genetic variation associated with circulating CRP and CRC-specific and all-cause mortality based on data from 1,235 individuals with CRC within the European Prospective Investigation into Cancer and Nutrition cohort using multivariable-adjusted Cox proportional hazards regression. During a median follow-up of 9.3 years, 455 CRC-specific deaths were recorded, out of 590 deaths from all causes. Pre-diagnostic CRP concentrations were not associated with CRC-specific (hazard ratio, HR highest versus lowest quintile 0.92, 95% confidence interval, CI 0.66, 1.28) or all-cause mortality (HR 0.91, 95% CI 0.68, 1.21). Genetic predisposition to higher CRP (weighted score based on alleles of four CRP SNPs associated with higher circulating CRP) was not significantly associated with CRC-specific mortality (HR per CRP-score unit 0.95, 95% CI 0.86, 1.05) or all-cause mortality (HR 0.98, 95% CI 0.90, 1.07). Among four investigated CRP genetic variants, only SNP rs1205 was significantly associated with CRC-specific (comparing the CT and CC genotypes with TT genotype, HR 0.54, 95% CI 0.35, 0.83 and HR 0.58, 95% CI 0.38, 0.88, respectively) and all-cause mortality (HR 0.58, 95% CI 0.40, 0.85 and 0.64, 95% CI 0.44, 0.92, respectively). The results of this prospective cohort study do not support a role of pre-diagnostic CRP concentrations on mortality in individuals with CRC. The observed associations with rs1205 deserve further scientific attention.
%K Humans
%K Prospective Studies
%K Risk Factors
%~