RT Journal Article
T1 The Role of Autophagy in White Adipose Tissue Function: Implications for Metabolic Health
A1 Clemente-Postigo, Mercedes
A1 Tinahones, Alberto
A1 El Bekay, Rajaa
A1 Malagón, María M.
A1 Tinahones, Francisco J.
K1 Adipose tissue
K1 Adipocyte
K1 Autophagy
K1 Obesity
K1 Diabetes
K1 Metabolism
K1 Tejido adiposo
K1 Adipocitos
K1 Autofagia
K1 Obesidad
K1 Diabetes Mellitus
K1 Metabolismo
AB White adipose tissue (WAT) is a highly adaptive endocrine organ that continuously remodels in response to nutritional cues. WAT expands to store excess energy by increasing adipocyte number and/or size. Failure in WAT expansion has serious consequences on metabolic health resulting in altered lipid, glucose, and inflammatory profiles. Besides an impaired adipogenesis, fibrosis and low-grade inflammation also characterize dysfunctional WAT. Nevertheless, the precise mechanisms leading to impaired WAT expansibility are yet unresolved. Autophagy is a conserved and essential process for cellular homeostasis, which constitutively allows the recycling of damaged or long-lived proteins and organelles, but is also highly induced under stress conditions to provide nutrients and remove pathogens. By modulating protein and organelle content, autophagy is also essential for cell remodeling, maintenance, and survival. In this line, autophagy has been involved in many processes affected during WAT maladaptation, including adipogenesis, adipocyte, and macrophage function, inflammatory response, and fibrosis. WAT autophagy dysregulation is related to obesity and diabetes. However, it remains unclear whether WAT autophagy alteration in obese and diabetic patients are the cause or the consequence of WAT malfunction. In this review, current data regarding these issues are discussed, focusing on evidence from human studies.
PB MDPI
YR 2020
FD 2020-04-30
LK http://hdl.handle.net/10668/3533
UL http://hdl.handle.net/10668/3533
LA en
NO Clemente-Postigo M, Tinahones A, El Bekay R, Malagón MM, Tinahones FJ. The Role of Autophagy in White Adipose Tissue Function: Implications for Metabolic Health. Metabolites. 2020 Apr 30;10(5):179
DS RISalud
RD Apr 6, 2025