RT Journal Article
T1 Adipose tissue concentrations of non-persistent environmental phenols and local redox balance in adults from Southern Spain.
A1 Artacho-Cordón, F
A1 Ríos-Arrabal, S
A1 León, J
A1 Frederiksen, H
A1 Sáenz, J M
A1 Martín-Olmedo, P
A1 Fernández, M F
A1 Olea, N
A1 Arrebola, J P
K1 Adipose tissue
K1 Environmental phenols
K1 Oxidative stress
K1 Parabens
AB The aim was to evaluate the associations of environmental phenol and paraben concentrations with the oxidative microenvironment in adipose tissue. This study was conducted in a subsample (n = 144) of the GraMo cohort (Southern Spain). Concentrations of 9 phenols and 7 parabens, and levels of oxidative stress biomarkers were quantified in adipose tissue. Associations were estimated using multivariable linear regression analyses adjusted for potential confounders. Benzophenone-3 (BP-3) concentration was borderline associated with enhanced glutathione peroxidase (GPx) activity [exp(β) = 1.20, p = 0.060] and decreased levels of reduced glutathione (GSH) [exp(β) = 0.55, p = 0.070]. Concentrations of bisphenol A (BPA) and methylparaben (MeP) were associated to lower glutathione reductase (GRd) activity [exp(β) = 0.83, exp(β) = 0.72, respectively], and BPA was borderline associated to increased levels of oxidized glutathione (GSSG) [exp(β) = 1.73, p-value = 0.062]. MeP was inversely associated to both hemeoxygenase-1 (HO-1) and superoxide dismustase (SOD) activity, as well as to the levels of thiobarbituric acid reactive substances (TBARS) [0.75 
YR 2019
FD 2019-10-11
LK http://hdl.handle.net/10668/14734
UL http://hdl.handle.net/10668/14734
LA en
DS RISalud
RD Mar 14, 2025