%0 Journal Article
%A Artacho-Cordón, F
%A Ríos-Arrabal, S
%A León, J
%A Frederiksen, H
%A Sáenz, J M
%A Martín-Olmedo, P
%A Fernández, M F
%A Olea, N
%A Arrebola, J P
%T Adipose tissue concentrations of non-persistent environmental phenols and local redox balance in adults from Southern Spain.
%D 2019
%U http://hdl.handle.net/10668/14734
%X The aim was to evaluate the associations of environmental phenol and paraben concentrations with the oxidative microenvironment in adipose tissue. This study was conducted in a subsample (n = 144) of the GraMo cohort (Southern Spain). Concentrations of 9 phenols and 7 parabens, and levels of oxidative stress biomarkers were quantified in adipose tissue. Associations were estimated using multivariable linear regression analyses adjusted for potential confounders. Benzophenone-3 (BP-3) concentration was borderline associated with enhanced glutathione peroxidase (GPx) activity [exp(β) = 1.20, p = 0.060] and decreased levels of reduced glutathione (GSH) [exp(β) = 0.55, p = 0.070]. Concentrations of bisphenol A (BPA) and methylparaben (MeP) were associated to lower glutathione reductase (GRd) activity [exp(β) = 0.83, exp(β) = 0.72, respectively], and BPA was borderline associated to increased levels of oxidized glutathione (GSSG) [exp(β) = 1.73, p-value = 0.062]. MeP was inversely associated to both hemeoxygenase-1 (HO-1) and superoxide dismustase (SOD) activity, as well as to the levels of thiobarbituric acid reactive substances (TBARS) [0.75 
%K Adipose tissue
%K Environmental phenols
%K Oxidative stress
%K Parabens
%~