TY - JOUR AU - Jiménez-Medina, Eva AU - Berruguilla, Enrique AU - Romero, Irene AU - Algarra, Ignacio AU - Collado, Antonia AU - Garrido, Federico AU - Garcia-Lora, Angel PY - 2008 DO - 10.1186/1471-2407-8-78 UR - http://hdl.handle.net/10668/644 T2 - BMC Cancer AB - BACKGROUNDProtein-bound polysaccharide (PSK) is derived from the CM-101 strain of the fungus Coriolus versicolor and has shown anticancer activity in vitro and in in vivo experimental models and human cancers. Several randomized clinical trials have... LA - en PB - BioMed Central KW - Animales KW - Apoptosis KW - Ciclo Celular KW - Línea Celular KW - Proliferación de la Célula KW - Ensayos de Selección de Medicamentos Antitumorales KW - Proteínas Fúngicas KW - Hongos KW - Células HeLa KW - Humanos KW - Factores Inmunológicos KW - Células Jurkat KW - Linfocitos KW - Melanoma Experimental KW - Ratones KW - Polisacáridos KW - Proteoglicanos KW - Medical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Death::Apoptosis KW - Medical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Cycle KW - Medical Subject Headings::Anatomy::Cells::Cells, Cultured::Cell Line::Cell Line, Tumor KW - Medical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Growth Processes::Cell Proliferation KW - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Clinical Laboratory Techniques::Cytological Techniques::Drug Screening Assays, Antitumor KW - Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Fungal Proteins KW - Medical Subject Headings::Organisms::Eukaryota::Fungi KW - Medical Subject Headings::Anatomy::Cells::Cells, Cultured::Cell Line::Cell Line, Tumor::HeLa Cells KW - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans KW - Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Physiological Effects of Drugs::Immunologic Factors KW - Medical Subject Headings::Anatomy::Cells::Cells, Cultured::Cell Line::Cell Line, Tumor::Jurkat Cells KW - Medical Subject Headings::Anatomy::Cells::Blood Cells::Leukocytes::Leukocytes, Mononuclear::Lymphocytes KW - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Models, Animal::Disease Models, Animal::Neoplasms, Experimental::Melanoma, Experimental KW - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Mice KW - Medical Subject Headings::Chemicals and Drugs::Carbohydrates::Polysaccharides KW - Medical Subject Headings::Chemicals and Drugs::Carbohydrates::Polysaccharides::Proteoglycans TI - The immunomodulator PSK induces in vitro cytotoxic activity in tumour cell linesvia arrest of cell cycle and induction of apoptosis TY - research article ER -