RT Conference Proceedings
T1 Iron overload, an immunosuppression marker in HIV-infected patients.
A1 López-Calderón, C
A1 Palacios, R
A1 Cobo, A
A1 Moreno, T
A1 Ruiz, J
A1 Nuño, E
A1 Márquez, M
A1 Santos, J
K1 Infecciones por VIH
K1 Sobrecarga de Hierro
K1 Síndrome X Metabólico
K1 Inmunosupresión
K1 Seropositividad para VIH
K1 VIH
K1 Quimioterapia
K1 Análisis Químico de la Sangre
K1 Enfermedades Bacterianas de Transmisión Sexual
AB Purpose: Iron overload (IO) has been associated with increased cardiovascular risk (CVR) and metabolic syndrome (MS) in the general population; both elevated CVR and MS are frequent in HIV- patients. Our aim was to analyze the prevalence of IO in a cohort of asymptomatic patients with HIV infection, and related factors. Methods: Cross-sectional study of a cohort of HIV outpatients in regular follow-up. Demographic, epidemiological, clinical, analytical and therapeutic data were collected. Patients completed a questionnaire about CVR factors and 10-year CV disease risk estimation (Framingham score), underwent a physical exam, and a fasting blood analysis. IO was defined as a plasma ferritin level higher than 200 m/L in women and 300 m/L in men. Results: 571 patients (446 men, 125 women), with a mean age of 43.2 years, sexual transmission of HIV in 68.5%, median CD4 count 474 cell/μL (IQR: 308-666), and 36.3% Aids cases 86.2% were on antiretroviral therapy (ART), and 74.8% of them had undetectable HIV viral load 14.6% met MS criteria, and mean CVR at 10 years was 6.67%. IO was detected in 11% of cases. Patients with IO were more immunosuppressed (CD4 count 369 vs 483/μL, p<0.0001), presented a higher prevalence of detectable HIV viral load (17.6% vs 8.9%; p<0.005), and of Aids cases (14.9% vs 8.7%; p<0.023), and lower plasma levels of cholesterol, HDLc and LDLc (154 vs 183, 34 vs 43, 93 vs 110 mg/dL, respectively; p<0.0001. In the multivariate analysis, the only related factor was CD4 count <350 cell/μL (OR 2.86, 95% CI 1.6-4.9; p<0.0001). IO was not associated with CVR nor with MS. Conclusions: IO is not uncommon in HIV patients, and it is only related with immunosuppression defined as CD4 count <350 cell/ mL, and in contrast to general population, it is not related with increased CVR nor with MS.
PB BioMed Central
YR 2012
FD 2012-11-11
LK http://hdl.handle.net/10668/1414
UL http://hdl.handle.net/10668/1414
LA en
NO López-Calderón C., Palacios R., Cobo A., Moreno T., Ruiz J., Nuño E. et al. Iron overload, an immunosuppression marker in HIV-infected patients. Journal of the International AIDS Society. 2012;15(Suppl. 4):18304
DS RISalud
RD Apr 12, 2025