TY  - GEN
AU  - Segovia-Zafra, Antonio
AU  - Zeo-Sanchez, Daniel E. Di
AU  - Lopez-Gomez, Carlos
AU  - Perez-Valdes, Zeus
AU  - Garcia-Fuentes, Eduardo
AU  - Andrade, Raul J.
AU  - Lucena, M. Isabel
AU  - Villanueva-Paz, Marina
PY  - 2021
DO  - 10.1016/j.apsb.2021.11.013
SN  - 2211-3835
UR  - https://hdl.handle.net/10668/26940
T2  - Acta pharmaceutica sinica b
AB  - Idiosyncratic drug-induced liver injury (iDILI) encompasses the unexpected harms that prescription and non-prescription drugs, herbal and dietary supplements can cause to the liver. iDILI remains a major public health problem and a major cause of drug...
LA  - en
PB  - Inst materia medica, chinese acad medical sciences
KW  - Drug-induced liver injury
KW  - Preclinical models
KW  - Mechanisms
KW  - Oxidative stress
KW  - Mitochondrial damage
KW  - Immune response
KW  - Personalized medicine
KW  - Hepatocyte-like cells
KW  - Pluripotent stem-cells
KW  - In-silico models
KW  - Endoplasmic-reticulum stress
KW  - Necrosis-factor-alpha
KW  - Gamma-glutamylcysteine synthetase
KW  - Induced mitochondrial dysfunction
KW  - Lymphocyte-transformation test
KW  - Sandwich-cultured hepatocytes
KW  - Acid-induced toxicity
TI  - Preclinical models of idiosyncratic drug-induced liver injury (iDILI): Moving towards prediction
TY  - review
VL  - 11
ER  -