RT Journal Article
T1 Eosinophils engulfing platelets and with ring-shaped nuclei in nivolumab-associated eosinophilia.
A1 Delgado-Serrano, Javier
A1 Morales-Camacho, Rosario M
A1 Caballero-Velazquez, Teresa
A1 Garcia-Canale, Silvia
A1 Vargas, M Teresa
A1 Prats-Martin, Concepcion
K1 Middle Aged
K1 Humans
K1 Blood Platelets
AB A 63-year-old male smoker had been diagnosed with stage IVTTF1+( thyroid transcription factor -1) lung adenocarcinoma oneyear ago. Four cycles of carboplatin and pemetrexed were admin-istered without response. Thereafter, he was treated with nivolu-mab 240 mg intravenously every two weeks. Following thesecond cycle, eosinophilia was detected for which no other causewas found. A partial response of the cancer was achieved andtreatment was continued despite asymptomatic and progressiveeosinophilia which reached a maximum of 1039109/l eosino-phils after the tenth nivolumab cycle. Examination of the periph-eral blood film showed eosinophils with ring-shaped nuclei (1–2/1000) (bottom) and platelet phagocytosis by eosinophils (<1/1000) (top). Cytopenias were not detected. Despite treatmentwith prednisone 30 mg/day, eosinophilia persisted (719109/l)but with no associated clinical symptoms. PDGFRA, PDGFRB ,FGFR1 and JAK2 rearrangements were negative
PB Wiley-Blackwell Publishing Ltd.
YR 2020
FD 2020-03-12
LK http://hdl.handle.net/10668/15085
UL http://hdl.handle.net/10668/15085
LA en
NO Delgado-Serrano J, Morales-Camacho RM, Caballero-Velázquez T, García-Canale S, Vargas MT, Prats-Martín C. Eosinophils engulfing platelets and with ring-shaped nuclei in nivolumab-associated eosinophilia. Br J Haematol. 2020 Mar;188(6):812.
DS RISalud
RD Jun 1, 2025