RT Journal Article T1 Prospective associations between a priori dietary patterns adherence and kidney function in an elderly Mediterranean population at high cardiovascular risk. A1 Valle-Hita, Cristina A1 Diaz-Lopez, Andres A1 Becerra-Tomas, Nerea A1 Martinez-Gonzalez, Miguel A A1 Garcia, Veronica Ruiz A1 Corella, Dolores A1 Goday, Albert A1 Martinez, J Alfredo A1 Alonso-Gómez, Angel M A1 Wärnberg, Julia A1 Vioque, Jesus A1 Romaguera, Dora A1 Lopez-Miranda, Jose A1 Estruch, Ramon A1 Tinahones, Francisco J A1 Lapetra, Jose A1 Serra-Majem, Luis A1 Cano-Ibañez, Naomi A1 Tur, Josep A A1 Rubin-Garcia, Maria A1 Pinto, Xavier A1 Delgado-Rodriguez, Miguel A1 Matia-Martin, Pilar A1 Vidal, Josep A1 Fontao, Sebastian Mas A1 Daimiel, Lidia A1 Ros, Emilio A1 Toledo, Estefania A1 Sorli, Jose V A1 Roca, C A1 Abete, Iztiar A1 Moreno-Rodriguez, Anai A1 Crespo-Oliva, Edelys A1 Candela-Garcia, Inmaculada A1 Morey, Marga A1 Garcia-Rios, Antonio A1 Casas, Rosa A1 Fernandez-Garcia, Jose Carlos A1 Santos-Lozano, Jose Manuel A1 Diez-Espino, Javier A1 Ortega-Azorin, Carolina A1 Comas, M A1 Zulet, M Angeles A1 Sorto-Sanchez, Carolina A1 Ruiz-Canela, Miguel A1 Fito, Montse A1 Salas-Salvado, Jordi A1 Babio, Nancy K1 DASH diet K1 Dietary patterns K1 Glomerular filtration rate K1 Kidney function K1 Mediterranean diet K1 Protein diet score AB To assess the association between three different a priori dietary patterns adherence (17-item energy reduced-Mediterranean Diet (MedDiet), Trichopoulou-MedDiet and Dietary Approach to Stop Hypertension (DASH)), as well as the Protein Diet Score and kidney function decline after one year of follow-up in elderly individuals with overweight/obesity and metabolic syndrome (MetS). We prospectively analyzed 5675 participants (55-75 years) from the PREDIMED-Plus study. At baseline and at one year, we evaluated the creatinine-based estimated glomerular filtration rate (eGFR) and food-frequency questionnaires-derived dietary scores. Associations between four categories (decrease/maintenance and tertiles of increase) of each dietary pattern and changes in eGFR (ml/min/1.73m2) or ≥ 10% eGFR decline were assessed by fitting multivariable linear or logistic regression models, as appropriate. Participants in the highest tertile of increase in 17-item erMedDiet Score showed higher upward changes in eGFR (β: 1.87 ml/min/1.73m2; 95% CI: 1.00-2.73) and had lower odds of ≥ 10% eGFR decline (OR: 0.62; 95% CI: 0.47-0.82) compared to individuals in the decrease/maintenance category, while Trichopoulou-MedDiet and DASH Scores were not associated with any renal outcomes. Those in the highest tertile of increase in Protein Diet Score had greater downward changes in eGFR (β: - 0.87 ml/min/1.73m2; 95% CI: - 1.73 to - 0.01) and 32% higher odds of eGFR decline (OR: 1.32; 95% CI: 1.00-1.75). Among elderly individuals with overweight/obesity and MetS, only higher upward change in the 17-item erMedDiet score adherence was associated with better kidney function after one year. However, increasing Protein Diet Score appeared to have an adverse impact on kidney health. PB Springer YR 2022 FD 2022-02-11 LK http://hdl.handle.net/10668/19908 UL http://hdl.handle.net/10668/19908 LA en NO Valle-Hita C, Díaz-López A, Becerra-Tomás N, Martínez-González MA, García VR, Corella D, et al. Prospective associations between a priori dietary patterns adherence and kidney function in an elderly Mediterranean population at high cardiovascular risk. Eur J Nutr. 2022 Sep;61(6):3095-3108 DS RISalud RD Apr 14, 2025