RT Journal Article
T1 Effect of Probiotics on Host-Microbiota in Bacterial Infections.
A1 Rueda-Robles, Ascension
A1 Rodriguez-Lara, Avilene
A1 Meyers, Matthew S
A1 Saez-Lara, Maria Jose
A1 Alvarez-Mercado, Ana I
K1 antibiotic resistance
K1 bacterial persistence
K1 infection
K1 microbiota
K1 pathogenic bacteria
K1 persisters
K1 probiotics
AB Diseases caused by bacteria cause millions of deaths every year. In addition, the problem of resistance to antibiotics is so serious that it threatens the achievements of modern medicine. This is a very important global problem as some bacteria can also develop persistence. Indeed, the persistence of pathogenic bacteria has evolved as a potent survival strategy to overcome host organisms' defense mechanisms. Additionally, chronic or persistent infections may be caused by persisters which could facilitate antibiotic resistance. Probiotics are considered good bacteria. It has been described that the modulation of gut microbiota by probiotics could have a great potential to counteract the deleterious impact and/or regulate gut microbiota after bacterial infection. Probiotics might provide health benefits through the inhibition of pathogen growth or the replacement of pathogenic bacteria. Bearing in mind that current strategies to avoid bacterial persistence and prevent antibiotic resistance are not effective, other strategies need to be assessed. We have carried out a comprehensive review, which included the reported literature between 2016 and 2021, highlighting the clinical trials that reported the probiotics' potential to regulate gut microbiota after bacterial infection and focusing in particular on the context of antibiotic resistance and persister cells.
PB MDPI AG
SN 2076-0817
YR 2022
FD 2022-08-25
LK http://hdl.handle.net/10668/21529
UL http://hdl.handle.net/10668/21529
LA en
NO Rueda-Robles A, Rodríguez-Lara A, Meyers MS, Sáez-Lara MJ, Álvarez-Mercado AI. Effect of Probiotics on Host-Microbiota in Bacterial Infections. Pathogens. 2022 Aug 29;11(9):986.
DS RISalud
RD Apr 4, 2025